P J Owen-Lynch
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Explore the profile of P J Owen-Lynch including associated specialties, affiliations and a list of published articles.
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21
Citations
168
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Recent Articles
11.
Owen-Lynch P, Czaplewski L, Hunter M, Whetton A
Leuk Lymphoma
. 1998 Jul;
30(1-2):41-53.
PMID: 9669675
The control of primitive haemopoietic progenitor cell proliferation in vitro can be achieved with combinations of growth stimulatory cytokines. Acting in apparent opposition to these growth stimulators are growth inhibitory...
12.
Pierce A, Whetton A, Owen-Lynch P, Tavernier J, Spooncer E, Dexter T, et al.
J Cell Sci
. 1998 May;
111 ( Pt 6):815-23.
PMID: 9472009
The interleukin-5 (IL-5) receptor is a heterodimer that consists of an IL-5 specific alpha subunit and a common ssc chain that is shared with the receptors for granulocyte macrophage colony...
13.
Pierce A, Heyworth C, Nicholls S, Spooncer E, Dexter T, Lord J, et al.
J Cell Biol
. 1998 Apr;
140(6):1511-8.
PMID: 9508782
Highly enriched, bipotent, hematopoietic granulocyte macrophage colony-forming cells (GM-CFC) require cytokines for their survival, proliferation, and development. GM-CFC will form neutrophils in the presence of the cytokines stem cell factor...
14.
Owen-Lynch P, Adams J, Brereton M, Czaplewski L, Whetton A, Yin J
Br J Haematol
. 1996 Oct;
95(1):77-84.
PMID: 8857942
The effects of recombinant macrophage inflammatory protein 1 alpha (rhMIP-1 alpha) on the proliferation of leukaemic blast cells from patients with acute myeloid leukaemia was assessed. Using the previously described...
15.
Chasty R, Lucas G, Owen-Lynch P, Pierce A, Whetton A
Blood
. 1995 Dec;
86(11):4270-7.
PMID: 7492787
The response of normal and chronic myeloid leukemia (CML), CD34+ cells to human macrophage inflammatory protein-1 alpha (MIP-1 alpha or LD78) was assessed. In tritiated thymidine incorporation assays, stem cell...
16.
Evans C, Lord J, Owen-Lynch P, Johnson G, Dive C, Whetton A
J Cell Sci
. 1995 Jul;
108 ( Pt 7):2591-8.
PMID: 7593300
We previously demonstrated that activation of v-ABL protein tyrosine kinase resulted in suppression of apoptosis following interleukin-3 removal using an interleukin-3-dependent haemopoietic cell line transfected with a temperature-sensitive mutant of...
17.
Owen-Lynch P, Wong A, Whetton A
J Biol Chem
. 1995 Mar;
270(11):5956-62.
PMID: 7534303
A temperature-sensitive mutant of the v-Abl protein has previously been shown to exhibit tyrosine protein kinase activity in Interleukin 3 (IL-3)-dependent IC.DP cells grown at the permissive temperature (32 degrees...
18.
Heyworth C, Pearson M, Dexter T, Wark G, Owen-Lynch P, Whetton A
Growth Factors
. 1995 Jan;
12(3):165-72.
PMID: 8619922
Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha) can inhibit the proliferation of multipotent haemopoietic cells. Using the FDCP-Mix A4 multipotent stem cell line, MIP-1 alpha was shown to inhibit 1L-3 stimulated...
19.
Whetton A, Heyworth C, Nicholls S, Evans C, Lord J, Dexter T, et al.
J Cell Biol
. 1994 May;
125(3):651-9.
PMID: 7513707
Granulocyte macrophage colony-forming cells (GM-CFC) have the potential to develop into either macrophages and/or neutrophils. With a highly enriched population of these cells we have found that although GM-CFC are...
20.
Spooncer E, Fairbairn L, Cowling G, Dexter T, Whetton A, Owen-Lynch P
Leukemia
. 1994 Apr;
8(4):620-30.
PMID: 8152257
A temperature sensitive abl protein tyrosine kinase gene was transferred into a multipotent haemopoietic stem cell line, and the primary biological effects of expression of the gene were examined at...