A D Whetton
Overview
Explore the profile of A D Whetton including associated specialties, affiliations and a list of published articles.
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Articles
102
Citations
871
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Recent Articles
1.
Pearson S, Williamson A, Blance R, Somervaille T, Taylor S, Azadbakht N, et al.
Leukemia
. 2017 Dec;
32(2):574.
PMID: 29257138
This corrects the article DOI: 10.1038/leu.2017.143.
2.
Pearson S, Williamson A, Blance R, Somervaille T, Taylor S, Azadbakht N, et al.
Leukemia
. 2017 May;
31(12):2717-2725.
PMID: 28533538
In excess of 90% of patients with polycythaemia vera (PV) express a mutated form of Janus kinase 2 (JAK2), JAK2V617F. Such aberrant proteins offer great potential for the treatment of...
3.
Tran D, Saran S, Dittrich-Breiholz O, Williamson A, Klebba-Farber S, Koch A, et al.
Cell Death Dis
. 2013 Oct;
4:e879.
PMID: 24157873
Hematopoiesis and commitment to a restricted lineage are guided by a timely expressed set of cytokine receptors and their downstream transcription factors. A member of the mRNA export complex, THOC5...
4.
Simpson K, Cawthorne C, Zhou C, Hodgkinson C, Walker M, Trapani F, et al.
Cell Death Dis
. 2013 May;
4:e613.
PMID: 23640455
Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in...
5.
Griaud F, Pierce A, Gonzalez Sanchez M, Scott M, Abraham S, Holyoake T, et al.
Leukemia
. 2012 Oct;
27(4):932-40.
PMID: 23032722
THOC5 is a member of the THO complex that is involved in processing and transport of mRNA. We have shown previously that hematopoietic stem cells have an absolute requirement for...
6.
Dobbin E, Graham C, Freeburn R, Unwin R, Griffiths J, Pierce A, et al.
Stem Cell Res
. 2010 Sep;
5(3):226-43.
PMID: 20875954
Objective proteomic analysis offers opportunities for hypothesis generation on molecular events associated with pathogenesis in stem cells. Relative quantification mass spectrometry was employed to identify pathways affected by Tel/PDGFRβ, an...
7.
Blankley R, Gaskell S, Whetton A, Dive C, Baker P, Myers J
BJOG
. 2009 Aug;
116(11):1473-80.
PMID: 19663911
Objective: Progress in the prevention and treatment of women at risk of pre-eclampsia (PE) still remains hindered by the lack of clinical screening tools that can accurately predict which mothers...
8.
Burthem J, Rees-Unwin K, Mottram R, Adams J, Lucas G, Spooncer E, et al.
Leukemia
. 2007 Jun;
21(8):1708-14.
PMID: 17554385
Evidence from cell line-based studies indicates that rho-kinase may play a role in the leukaemic transformation of human cells mediated by the BCR/ABL tyrosine kinase, manifest clinically as chronic myeloid...
9.
Mancini A, El Bounkari O, Norrenbrock A, Scherr M, Schaefer D, Eder M, et al.
Oncogene
. 2006 Aug;
26(7):1020-7.
PMID: 16909111
Fms interacting protein (FMIP) is a substrate for Fms tyrosine kinase, and a nuclear/cytoplasm shuttling protein with a leucine zipper. As the phosphorylation of FMIP is observed in insulin-stimulated preadipocytes,...
10.
Underhill-Day N, Pierce A, THOMPSON S, Xenaki D, Whetton A, Owen-Lynch P
Br J Haematol
. 2006 Feb;
132(6):774-83.
PMID: 16487179
Philadelphia chromosome-positive, chronic myeloid leukaemia (CML) stem and progenitor cells have a survival and growth advantage compared with their normal counterparts. The mechanisms through which the BCR/ABL protein tyrosine kinase...