P J Gilligan
Overview
Explore the profile of P J Gilligan including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
92
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Recent Articles
1.
Murray O, Bisset J, Gilligan P, Hannan M, Murray J
Clin Radiol
. 2020 Apr;
75(6):405-407.
PMID: 32299617
No abstract available.
2.
Gilligan P, Baldauf C, Cocuzza A, Chidester D, Zaczek R, Fitzgerald L, et al.
Bioorg Med Chem
. 2000 Sep;
8(1):181-9.
PMID: 10968277
Structure activity relationship studies led to the discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazo lo-[1,5-a]-pyrimidine 11-31 (DMP904), whose pharmacological profile strongly supports the hypothesis that hCRF1 antagonists may be potent anxiolytic drugs. Compound 11-31...
3.
Gilligan P, Robertson D, Zaczek R
J Med Chem
. 2000 May;
43(9):1641-60.
PMID: 10794681
No abstract available.
4.
He L, Gilligan P, Zaczek R, Fitzgerald L, McElroy J, Shen H, et al.
J Med Chem
. 2000 Feb;
43(3):449-56.
PMID: 10669572
Structure-activity studies in the pyrazolo[1,5-a]-1,3,5-triazine series led to the discovery that compound 11i (DMP696) is a potent hCRF(1) receptor antagonist (K(i) = 1.7 nM vs 7.5 nM for alpha-hel-CRF(9-41), hCRF(1)...
5.
Gilligan P, He L, Culp S, Fitzgerald L, Tam S, Wong Y
Bioorg Med Chem
. 2000 Jan;
7(11):2321-8.
PMID: 10632042
Structure-activity studies around the 4-position of 2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists suggest that there is a large lipophilic cavity in the rat CRF receptor, which can accommodate a wide...
6.
Beck J, Curry M, Chorvat R, Fitzgerald L, Gilligan P, Zaczek R, et al.
Bioorg Med Chem Lett
. 1999 May;
9(8):1185-8.
PMID: 10328310
A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics...
7.
Cocuzza A, Hobbs F, Arnold C, Chidester D, Yarem J, Culp S, et al.
Bioorg Med Chem Lett
. 1999 May;
9(7):1057-62.
PMID: 10230640
A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.
8.
Beck J, Arvanitis A, Curry M, Rescinito J, Fitzgerald L, Gilligan P, et al.
Bioorg Med Chem Lett
. 1999 May;
9(7):967-72.
PMID: 10230622
A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation....
9.
Chorvat R, Bakthavatchalam R, Beck J, Gilligan P, Wilde R, Cocuzza A, et al.
J Med Chem
. 1999 Mar;
42(5):833-48.
PMID: 10072681
The synthesis and CRF receptor binding affinities of several new series of N-aryltriazolo- and -imidazopyrimidines and -pyridines are described. These cyclized systems were prepared from appropriately substituted diaminopyrimidines or -pyridines...
10.
Hodge C, Aldrich P, Wasserman Z, FERNANDEZ C, Nemeth G, Arvanitis A, et al.
J Med Chem
. 1999 Mar;
42(5):819-32.
PMID: 10072680
As described in the preceding paper (Arvanitis et al. J. Med. Chem. 1999, 42), anilinopyrimidines I were identified as potent antagonists of corticotropin-releasing hormone-1 receptor (CRH1-R, also referred to as...