Thiazolo[4,5-d]pyrimidine Thiones and -ones As Corticotropin-releasing Hormone (CRH-R1) Receptor Antagonists

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 1999 May 18

PMID 10328310

Citations 5

Authors

J P Beck

M A Curry

R J Chorvat

L W Fitzgerald

P J Gilligan

R Zaczek

G L Trainor

Affiliations

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Abstract

A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.

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