P J Gilligan
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Explore the profile of P J Gilligan including associated specialties, affiliations and a list of published articles.
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15
Citations
92
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Recent Articles
11.
Arvanitis A, Gilligan P, Chorvat R, Cheeseman R, Christos T, Bakthavatchalam R, et al.
J Med Chem
. 1999 Mar;
42(5):805-18.
PMID: 10072679
Screening of our chemical library using a rat corticotropin-releasing hormone (CRH) receptor assay led to the discovery that 2-anilinopyrimidine 15-1 weakly displaced [125I]-0-Tyr-oCRH from rat frontal cortex homogenates when compared...
12.
Gilligan P, Kergaye A, Lewis B, McElroy J
J Med Chem
. 1994 Feb;
37(3):364-70.
PMID: 7905926
Sigma receptor ligands have been proposed to be potential antipsychotic drugs based on their activity profile in animal behavioral models and their indirect modulation of dopaminergic function. Compound 15 (DuP...
13.
Tam S, Steinfels G, Gilligan P, Schmidt W, Cook L
J Pharmacol Exp Ther
. 1992 Dec;
263(3):1167-74.
PMID: 1361572
It has been suggested that sigma receptor antagonists may be useful as antipsychotic drugs and that 5-hydroxytryptamine (5-HT2) receptor antagonists produce improvements of the negative symptoms of schizophrenia. [1-(Cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'- oxoethyl)-piperidine...
14.
Gilligan P, Cain G, Christos T, Cook L, Drummond S, Johnson A, et al.
J Med Chem
. 1992 Nov;
35(23):4344-61.
PMID: 1360026
sigma receptor ligands represent a new class of potential antipsychotic drugs. This paper presents the structure-activity relationships leading to novel disubstituted piperidine sigma ligands, which have little or no affinity...
15.
Rakitzis E, Gilligan P, Hoffman J
J Membr Biol
. 1978 Jun;
41(2):101-15.
PMID: 671522
A kinetic analysis of anion self-exchange in human red blood cells, in the presence of an irreversible inhibitor, is presented and applied to the study of the inactivation of sulfate...