P C Isakson
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Explore the profile of P C Isakson including associated specialties, affiliations and a list of published articles.
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96
Citations
3092
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Recent Articles
1.
Yaksh T, Dirig D, Conway C, Svensson C, Luo Z, Isakson P
J Neurosci
. 2001 Aug;
21(16):5847-53.
PMID: 11487607
Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective inhibitors of cyclooxygenase (COX)...
2.
Walker M, Kurumbail R, Kiefer J, Moreland K, Koboldt C, Isakson P, et al.
Biochem J
. 2001 Jul;
357(Pt 3):709-18.
PMID: 11463341
Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms, which include simple competitive, as well as slow binding and irreversible...
3.
Verburg K, Maziasz T, Weiner E, Loose L, Geis G, Isakson P
Am J Ther
. 2001 Apr;
8(1):49-64.
PMID: 11304658
Nonsteroidal anti-inflammatory drugs have been a mainstay in the treatment of inflammatory diseases such as rheumatoid arthritis. However, these agents can result in severe and occasionally life-threatening adverse effects that...
4.
Khanna I, Yu Y, Huff R, Weier R, Xu X, Koszyk F, et al.
J Med Chem
. 2000 Aug;
43(16):3168-85.
PMID: 10956225
A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2. 3-Pyridyl derived COX-2 selective inhibitor (25) exhibited...
5.
WHELTON A, Schulman G, Wallemark C, Drower E, Isakson P, Verburg K, et al.
Arch Intern Med
. 2000 May;
160(10):1465-70.
PMID: 10826459
Objective: To compare the effects of celecoxib, a cyclooxygenase 2-specific inhibitor, with the nonspecific cyclooxygenase 1 and 2 inhibitor naproxen on renal function in 29 healthy elderly subjects in a...
6.
Margalit A, Hauser S, Isakson P
Adv Exp Med Biol
. 2000 Feb;
469:165-8.
PMID: 10667326
No abstract available.
7.
Leese P, Hubbard R, Karim A, Isakson P, Yu S, Geis G
J Clin Pharmacol
. 2000 Feb;
40(2):124-32.
PMID: 10664917
Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) nonspecifically inhibit cyclooxygenase-1 (COX-1), an enzyme critical to normal platelet function, and COX-2, which mediates inflammatory response mechanisms. Celecoxib, an antiarthritic agent that inhibits COX-2...
8.
Emery P, Zeidler H, Kvien T, Guslandi M, NAUDIN R, Stead H, et al.
Lancet
. 1999 Dec;
354(9196):2106-11.
PMID: 10609815
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX), which leads to suppression of COX-1-mediated production of gastrointestinal-protective prostaglandins. Gastrointestinal injury is a common outcome. We compared the efficacy, safety, and...
9.
Simon L, Weaver A, Graham D, Kivitz A, Lipsky P, Hubbard R, et al.
JAMA
. 1999 Dec;
282(20):1921-8.
PMID: 10580457
Context: In vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not COX-1, suggesting that this drug may have anti-inflammatory and analgesic activity without adverse upper gastrointestinal (GI)...
10.
Bensen W, Fiechtner J, McMillen J, Zhao W, Yu S, Woods E, et al.
Mayo Clin Proc
. 1999 Nov;
74(11):1095-105.
PMID: 10560596
Objective: To compare the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, with those of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and placebo in the treatment of osteoarthritis of...