J L Masferrer
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Explore the profile of J L Masferrer including associated specialties, affiliations and a list of published articles.
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52
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2671
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Recent Articles
1.
Buys E, Zimmer D, Chickering J, Graul R, Chien Y, Profy A, et al.
Nitric Oxide
. 2018 Jun;
78:72-80.
PMID: 29859918
Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophophate (cGMP), transduces many of the physiological effects of the gasotransmitter NO....
2.
Anderson G, Keys K, De Ciechi P, Masferrer J
Inflamm Res
. 2009 Feb;
58(2):109-17.
PMID: 19184362
Objective And Design: To determine the effect of combinations of cyclooxygenase (COX) inhibitors and inhibitors of leukotriene (LT) syntheses on collagen induced arthritis (CIA) in mice. Methods: The CIA model...
3.
Koki A, Khan N, Woerner B, Seibert K, Harmon J, Dannenberg A, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2002 Jun;
66(1):13-8.
PMID: 12051953
Increased prostaglandins (PGs) are associated with many inflammatory pathophysiological conditions; and are synthesized from arachidonic acid by either of 2 enzymes, cyclooxygenase-1 (COX-1) or -2 (COX-2). Recent epidemiologic, expression, and...
4.
Alshafie G, Seibert K, Koki A, Masferrer J, Harris R
Anticancer Res
. 2002 Feb;
21(5):3425-32.
PMID: 11848504
Recent chemopreventive studies in our laboratories showed that the COX-2 inhibitor, celecoxib, inhibited the induction of mammary cancer by 7,12-dimethylbenz(a)anthracene (DMBA). In this study, we examined the relative chemopreventive effect...
5.
Khan K, Masferrer J, Woerner B, Soslow R, Koki A
Scand J Gastroenterol
. 2001 Aug;
36(8):865-9.
PMID: 11495083
Background: The cyclooxygenase (COX) enzymes exist in two related but unique isoforms (COX-1 and COX-2) and catalyze the formation of prostaglandins (PGs). COX-1 is constitutively expressed, and is responsible for...
6.
Kulkarni S, Rader J, Zhang F, Liapis H, Koki A, Masferrer J, et al.
Clin Cancer Res
. 2001 Mar;
7(2):429-34.
PMID: 11234900
Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2) is an important target for preventing epithelial malignancies. Little is known, however, about the expression of COX-2 in gynecological malignancies. By immunoblot...
7.
Grubbs C, Lubet R, Koki A, LEAHY K, Masferrer J, Steele V, et al.
Cancer Res
. 2000 Nov;
60(20):5599-602.
PMID: 11059745
Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may have a role in the prevention of human cancers. A number of preclinical studies have also suggested that inhibition of...
8.
Masferrer J, NEEDLEMAN P
Proc Natl Acad Sci U S A
. 2000 Nov;
97(23):12400-1.
PMID: 11058172
No abstract available.
9.
LEAHY K, Koki A, Masferrer J
Curr Med Chem
. 2000 Oct;
7(11):1163-70.
PMID: 11032965
Angiogenesis is the process by which new blood vessels are formed. This process supports normal physiology as well as contributes to progression of disease. Progressive rheumatoid arthritis and growth of...
10.
Khanna I, Yu Y, Huff R, Weier R, Xu X, Koszyk F, et al.
J Med Chem
. 2000 Aug;
43(16):3168-85.
PMID: 10956225
A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2. 3-Pyridyl derived COX-2 selective inhibitor (25) exhibited...