P C Isakson
Overview
Explore the profile of P C Isakson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
96
Citations
3092
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Gierse J, Koboldt C, Walker M, Seibert K, Isakson P
Biochem J
. 1999 Apr;
339 ( Pt 3):607-14.
PMID: 10215599
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostaglandins by cyclo-oxygenases (COX). The discovery of a second COX isoform (COX-2) associated with inflammation led to agents that selectively inhibit COX-2,...
12.
Sheng H, Shao J, OMahony C, Lamps L, Albo D, Isakson P, et al.
Oncogene
. 1999 Feb;
18(4):855-67.
PMID: 10023661
The precise role of TGF-beta in colorectal carcinogenesis is not clear. The purpose of this study was to determine the phenotypic alterations caused by chronic exposure to TGF-beta in non-transformed...
13.
Smith C, Zhang Y, Koboldt C, Muhammad J, Zweifel B, Shaffer A, et al.
Proc Natl Acad Sci U S A
. 1998 Oct;
95(22):13313-8.
PMID: 9789085
The enzymes cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. These lipid mediators play important roles...
14.
Simon L, Lanza F, Lipsky P, Hubbard R, Talwalker S, Schwartz B, et al.
Arthritis Rheum
. 1998 Sep;
41(9):1591-602.
PMID: 9751091
Objective: To investigate the efficacy and safety of SC-58635 (celecoxib), an antiinflammatory and analgesic agent that acts by selective cyclooxygenase 2 (COX-2) inhibition and is not expected to cause the...
15.
Nakayama M, Uchimura K, Zhu R, Nagayama T, Rose M, Stetler R, et al.
Proc Natl Acad Sci U S A
. 1998 Sep;
95(18):10954-9.
PMID: 9724811
The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it...
16.
Dirig D, Isakson P, Yaksh T
J Pharmacol Exp Ther
. 1998 Jun;
285(3):1031-8.
PMID: 9618405
Intrathecal administration of nonsteroidal anti-inflammatory drugs in the rat blocks the thermal hyperalgesia induced by tissue injury, which suggests a role for spinal cyclooxygenase (COX) products in this facilitated state....
17.
Margalit A, Hauser S, Zweifel B, Anderson M, Isakson P
Am J Physiol
. 1998 Mar;
274(2):R294-302.
PMID: 9486284
Intraperitoneal administration of urate crystals to mice reduced subsequent macrophage conversion of arachidonic acid (AA) to prostaglandins (PGs) and 12-hydroxyeicosatetraenoic acid for up to 6 h. In contrast, levels of...
18.
Zhang Y, Shaffer A, Portanova J, Seibert K, Isakson P
J Pharmacol Exp Ther
. 1998 Feb;
283(3):1069-75.
PMID: 9399978
PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles in the initiation of inflammation and pain. In the present study, we evaluated the role of COX-2-derived PGE2 in...
19.
Sheng G, Shao J, Sheng H, Hooton E, Isakson P, Morrow J, et al.
Gastroenterology
. 1997 Dec;
113(6):1883-91.
PMID: 9394727
Background & Aims: Constitutive expression of cyclooxygenase 2 (COX-2) has been found in 85% of colorectal cancers. Ras mutations are found in 50% of colorectal adenocarcinomas. The aim of this...
20.
Kaufmann W, Andreasson K, Isakson P, Worley P
Prostaglandins
. 1997 Nov;
54(3):601-24.
PMID: 9373877
Prostaglandins (PGs) were first described in the brain by Samuelsson over 30 years ago (Samuelsson, 1964). Since then a large number of studies have shown that PGs are formed in...