P B McCray Jr
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Explore the profile of P B McCray Jr including associated specialties, affiliations and a list of published articles.
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73
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2608
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Recent Articles
11.
Saiman L, Tabibi S, Starner T, San Gabriel P, Winokur P, Jia H, et al.
Antimicrob Agents Chemother
. 2001 Sep;
45(10):2838-44.
PMID: 11557478
Endogenous peptide antibiotics are under investigation as inhaled therapeutic agents for cystic fibrosis (CF) lung disease. The bactericidal activities of five cathelicidin peptides (LL37 [human], CAP18 [rabbit], mCRAMP [mouse], rCRAMP...
12.
Carothers D, Graham S, Jia H, Ackermann M, Tack B, McCray Jr P
Am J Rhinol
. 2001 Jul;
15(3):175-9.
PMID: 11453504
beta-Defensins are endogenous cationic peptides with broad-spectrum antimicrobial activity that are thought to play a role in the innate immune response. Two human beta-defensins, beta-defensin-1 (HBD-1) and beta-defensin-2 (HBD-2), have...
13.
Stein C, Kang Y, Sauter S, Townsend K, Staber P, Derksen T, et al.
Mol Ther
. 2001 Jun;
3(6):850-6.
PMID: 11407898
Gene therapy holds great promise for the treatment of a variety of inherited diseases, including hemophilia A and mucopolysaccharidosis type VII (MPS VII). In both these disorders, subnormal levels of...
14.
Sanlioglu S, Williams C, Samavati L, Butler N, Wang G, McCray Jr P, et al.
J Biol Chem
. 2001 Jun;
276(32):30188-98.
PMID: 11402028
Reactive oxygen species (ROS) are important second messengers generated in response to many types of environmental stress. In this setting, changes in intracellular ROS can activate signal transduction pathways that...
15.
Lamb F, Graeff R, Clayton G, Smith R, Schutte B, McCray Jr P
Am J Respir Cell Mol Biol
. 2001 Apr;
24(4):376-81.
PMID: 11306429
Human fetal bronchopulmonary epithelia secrete liquid, and this chloride (Cl)-dependent process is important for normal lung growth. At the time of birth there is a maturational transition from a secretory...
16.
Sawai M, Jia H, Liu L, Aseyev V, Wiencek J, McCray Jr P, et al.
Biochemistry
. 2001 Apr;
40(13):3810-6.
PMID: 11300761
Human beta-defensin-2 (HBD-2) is a member of the defensin family of antimicrobial peptides. HBD-2 was first isolated from inflamed skin where it is posited to participate in the killing of...
17.
Slepushkin V, Staber P, Wang G, McCray Jr P, Davidson B
Mol Ther
. 2001 Mar;
3(3):395-402.
PMID: 11273782
Three subtypes of influenza A virus cause human disease: H1N1, H2N2, and H3N2. Although all result in respiratory illness, little is known about how these subtypes infect differentiated airway epithelia....
18.
Wang G, Sinn P, McCray Jr P
Curr Opin Mol Ther
. 2001 Mar;
2(5):497-506.
PMID: 11249752
Retroviral vectors offer several potential advantages for attaining persistent expression of a therapeutic gene in airway epithelia for diseases such as cystic fibrosis. However, several problems have limited their application....
19.
Jia H, Schutte B, Schudy A, Linzmeier R, Guthmiller J, Johnson G, et al.
Gene
. 2001 Feb;
263(1-2):211-8.
PMID: 11223260
Epithelial beta-defensins are broad-spectrum cationic antimicrobial peptides that also act as chemokines for adaptive immune cells. In the human genome, all known defensin genes cluster to a <1 Mb region...
20.
Drouin S, Kildsgaard J, Haviland J, Zabner J, Jia H, McCray Jr P, et al.
J Immunol
. 2001 Feb;
166(3):2025-32.
PMID: 11160252
The presence of the complement-derived anaphylatoxin peptides, C3a and C5a, in the lung can induce respiratory distress characterized by contraction of the smooth muscle walls in bronchioles and pulmonary arteries...