Ozkan Sari
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Explore the profile of Ozkan Sari including associated specialties, affiliations and a list of published articles.
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13
Citations
101
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Recent Articles
1.
Zhou L, Zhang H, Li C, De Schutter C, Sari O, Mengshetti S, et al.
ACS Omega
. 2022 Jan;
7(1):1452-1461.
PMID: 35036807
We present a newly developed synthetic route to 2-bromo-2-fluoro ribolactone based on our published 2-chloro-2-fluoro ribolactone synthesis. Stereoselective fluorination is key to controlling the 2-diastereoselectivity. We also report a substantially...
2.
Amblard F, Boucle S, Bassit L, Chen Z, Sari O, Cox B, et al.
Bioorg Med Chem
. 2021 Jan;
31:115952.
PMID: 33421915
Chronic hepatitis B viral infection is a significant health problem world-wide, and currently available antiviral agents suppress HBV infections, but rarely cure this disease. It is presumed that antiviral agents...
3.
Amblard F, Boucle S, Bassit L, Cox B, Sari O, Tao S, et al.
Antimicrob Agents Chemother
. 2020 Aug;
64(9).
PMID: 32819965
No abstract available.
4.
Amblard F, Boucle S, Bassit L, Cox B, Sari O, Tao S, et al.
Antimicrob Agents Chemother
. 2019 Nov;
64(2).
PMID: 31712213
Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of...
5.
Mengshetti S, Zhou L, Sari O, De Schutter C, Zhang H, Cho J, et al.
J Med Chem
. 2019 Jan;
62(4):1859-1874.
PMID: 30653317
Hepatitis C virus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of resistant virus, and are some of the most potent direct-acting agents with durable sustained...
6.
De Schutter C, Sari O, Coats S, Amblard F, Schinazi R
J Org Chem
. 2017 Nov;
82(24):13171-13178.
PMID: 29140703
A novel and efficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described. This approach takes advantage of a highly efficient diastereoselective electrophilic fluorination reaction (94% yield; >50:1 dr).
7.
Sari O, Boucle S, Cox B, Ozturk T, Russell O, Bassit L, et al.
Eur J Med Chem
. 2017 Jul;
138:407-421.
PMID: 28688280
The synthesis of novel series of sulfamoylbenzamides as HBV capsid assembly effector is reported. The structure was divided into five parts which were independently modified as part of our lead...
8.
Zhou S, Mahmoud S, Liu P, Zhou L, Ehteshami M, Bassit L, et al.
J Med Chem
. 2017 Jun;
60(13):5424-5437.
PMID: 28595015
Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete sustained virologic response in humans. Herein, we report, the...
9.
Sari O, Bassit L, Gavegnano C, McBrayer T, McCormick L, Cox B, et al.
Tetrahedron Lett
. 2017 Feb;
58(7):642-644.
PMID: 28163339
Herein, we report the synthesis of novel 2',2',3',3'-tetrafluorinated nucleoside analogs along with their phosphoramidate prodrugs. A tetrafluoro ribose moiety was coupled with different Boc/benzoyl-protected nucleobases under Mitsunobu conditions. After deprotection,...
10.
Sari O, Roy V, Metifiot M, Marchand C, Pommier Y, Bourg S, et al.
Eur J Med Chem
. 2015 Oct;
104:127-38.
PMID: 26451771
The synthesis and antiviral evaluation of a series of dihydropyrimidinone and thiopyrimidine derivatives bearing aryl α,γ-diketobutanoic acid moiety are described using the Biginelli multicomponent reaction as key step. The most...