Orian Shirihai
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Explore the profile of Orian Shirihai including associated specialties, affiliations and a list of published articles.
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40
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4382
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Recent Articles
11.
Momcilovic M, Jones A, Bailey S, Waldmann C, Li R, Lee J, et al.
Nature
. 2020 Jan;
577(7791):E7.
PMID: 31896820
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
12.
Momcilovic M, Jones A, Bailey S, Waldmann C, Li R, Lee J, et al.
Nature
. 2019 Nov;
575(7782):380-384.
PMID: 31666695
Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial role in sustaining the growth and survival of cancer cells. A central function of mitochondria is the...
13.
Salazar C, Elorza A, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz L
J Cell Physiol
. 2019 Feb;
234(10):17405-17419.
PMID: 30779122
HIG2A promotes cell survival under hypoxia and mediates the assembly of complex III and complex IV into respiratory chain supercomplexes. In the present study, we show that human HIGD2A and...
14.
Moore T, Zhou Z, Cohn W, Norheim F, Lin A, Kalajian N, et al.
Mol Metab
. 2018 Dec;
21:51-67.
PMID: 30591411
Objective: Mitochondria are organelles primarily responsible for energy production, and recent evidence indicates that alterations in size, shape, location, and quantity occur in response to fluctuations in energy supply and...
15.
Waters L, Ahsan F, Wolf D, Shirihai O, Teitell M
iScience
. 2018 Sep;
5:99-109.
PMID: 30240649
B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports naive B cell activation to enable...
16.
Xu S, Catapang A, Braas D, Stiles L, Doh H, Lee J, et al.
Cancer Metab
. 2018 Jul;
6:7.
PMID: 29988332
Background: Precision medicine therapies require identification of unique molecular cancer characteristics. Hexokinase (HK) activity has been proposed as a therapeutic target; however, different hexokinase isoforms have not been well characterized...
17.
Mahdaviani K, Benador I, Shirihai O
Bio Protoc
. 2018 May;
5(21).
PMID: 29770346
Brown adipose tissue (BAT) has the unique ability to dramatically increase mitochondrial uncoupled fuel oxidation for thermogenesis in response to adrenergic stimulation. A key parameter in assessing brown adipocyte thermogenic...
18.
Rodriguez-Nuevo A, Diaz-Ramos A, Noguera E, Diaz-Saez F, Duran X, Munoz J, et al.
EMBO J
. 2018 Apr;
37(10).
PMID: 29632021
Opa1 participates in inner mitochondrial membrane fusion and cristae morphogenesis. Here, we show that muscle-specific Opa1 ablation causes reduced muscle fiber size, dysfunctional mitochondria, enhanced Fgf21, and muscle inflammation characterized...
19.
Zhou Z, Ribas V, Rajbhandari P, Drew B, Moore T, Fluitt A, et al.
J Biol Chem
. 2018 Jan;
293(13):4735-4751.
PMID: 29378845
Estrogen receptor α (ERα) action plays an important role in pancreatic β-cell function and survival; thus, it is considered a potential therapeutic target for the treatment of type 2 diabetes...
20.
Alsabeeh N, Chausse B, Kakimoto P, Kowaltowski A, Shirihai O
Biochim Biophys Acta Mol Cell Biol Lipids
. 2017 Nov;
1863(2):143-151.
PMID: 29155055
High plasma levels of fatty acids occur in a variety of metabolic diseases. Cellular effects of fatty acid overload resulting in negative cellular responses (lipotoxicity) are often studied in vitro,...