Alexander M van der Bliek
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Explore the profile of Alexander M van der Bliek including associated specialties, affiliations and a list of published articles.
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36
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4841
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Recent Articles
1.
Kolitsida P, Saha A, Caliri A, Assali E, Riera A, Itskanov S, et al.
bioRxiv
. 2024 Aug;
PMID: 39149365
Mfn2 is a mitochondrial outer membrane fusion protein with the additional role of tethering mitochondria to the ER. Here, we describe a novel connection between Mfn2 and calcium release from...
2.
Zhou Z, Ma A, Moore T, Wolf D, Yang N, Tran P, et al.
Sci Adv
. 2024 Apr;
10(14):eadl0389.
PMID: 38569044
The dynamin-related guanosine triphosphatase, Drp1 (encoded by ), plays a central role in mitochondrial fission and is requisite for numerous cellular processes; however, its role in muscle metabolism remains unclear....
3.
Campos J, Marchesi Bozi L, Krum B, Grassmann Bechara L, Ferreira N, Arini G, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(2):e2204750120.
PMID: 36595699
Exercise is a nonpharmacological intervention that improves health during aging and a valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently alters mitochondrial functionality and metabolism. Mitochondrial...
4.
Segawa M, Wolf D, Hultgren N, Williams D, van der Bliek A, Shackelford D, et al.
Life Sci Alliance
. 2020 Jun;
3(7).
PMID: 32499316
Recent breakthroughs in live-cell imaging have enabled visualization of cristae, making it feasible to investigate the structure-function relationship of cristae in real time. However, quantifying live-cell images of cristae in...
5.
Wolf D, Segawa M, Kondadi A, Anand R, Bailey S, Reichert A, et al.
EMBO J
. 2019 Oct;
38(22):e101056.
PMID: 31609012
The mitochondrial membrane potential (ΔΨ ) is the main driver of oxidative phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae and inner boundary membranes (IBM), is considered to...
6.
Moore T, Zhou Z, Cohn W, Norheim F, Lin A, Kalajian N, et al.
Mol Metab
. 2018 Dec;
21:51-67.
PMID: 30591411
Objective: Mitochondria are organelles primarily responsible for energy production, and recent evidence indicates that alterations in size, shape, location, and quantity occur in response to fluctuations in energy supply and...
7.
Bohler P, Stuhldreier F, Anand R, Kondadi A, Schlutermann D, Berleth N, et al.
Cell Death Dis
. 2018 Feb;
9(3):286.
PMID: 29459714
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca and the initiation of apoptosis. Compounds that interfere with these functions...
8.
Zhou Z, Ribas V, Rajbhandari P, Drew B, Moore T, Fluitt A, et al.
J Biol Chem
. 2018 Jan;
293(13):4735-4751.
PMID: 29378845
Estrogen receptor α (ERα) action plays an important role in pancreatic β-cell function and survival; thus, it is considered a potential therapeutic target for the treatment of type 2 diabetes...
9.
van der Bliek A, Sedensky M, Morgan P
Genetics
. 2017 Nov;
207(3):843-871.
PMID: 29097398
Mitochondria are best known for harboring pathways involved in ATP synthesis through the tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding these roles were made with mutants affecting...
10.