Timothy M Moore
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Explore the profile of Timothy M Moore including associated specialties, affiliations and a list of published articles.
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32
Citations
629
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Recent Articles
1.
Zhou Z, Ma A, Moore T, Wolf D, Yang N, Tran P, et al.
Sci Adv
. 2024 Apr;
10(14):eadl0389.
PMID: 38569044
The dynamin-related guanosine triphosphatase, Drp1 (encoded by ), plays a central role in mitochondrial fission and is requisite for numerous cellular processes; however, its role in muscle metabolism remains unclear....
2.
Moore T, Lee S, Olsen T, Morselli M, Strumwasser A, Lin A, et al.
Cell Rep
. 2023 May;
42(5):112499.
PMID: 37178122
Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise intervention in middle-aged men and a panel of...
3.
Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, et al.
Nat Commun
. 2022 Nov;
13(1):6661.
PMID: 36333379
Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue remain unclear....
4.
Herbst A, Aiken J, Kim C, Gushue D, McKenzie D, Moore T, et al.
Geroscience
. 2022 Sep;
45(1):555-567.
PMID: 36178599
Beta-guanidinopropionic acid (GPA) is a creatine analog suggested as a treatment for hypertension, diabetes, and obesity, which manifest primarily in older adults. A notable side effect of GPA is the...
5.
Cao Y, Vergnes L, Wang Y, Pan C, Chella Krishnan K, Moore T, et al.
Nat Commun
. 2022 Jul;
13(1):3850.
PMID: 35787630
Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex differences might underlie this bias. As...
6.
Moore T, Terrazas A, Strumwasser A, Lin A, Zhu X, Anand A, et al.
Physiol Rep
. 2021 Nov;
9(21):e15068.
PMID: 34755487
The metabolic syndrome is a cluster of conditions that increase an individual's risk of developing diseases. Being physically active throughout life is known to reduce the prevalence and onset of...
7.
Chella Krishnan K, Vergnes L, Acin-Perez R, Stiles L, Shum M, Ma L, et al.
Nat Metab
. 2021 Oct;
3(11):1552-1568.
PMID: 34697471
We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex differences affect adipose mitochondrial function and metabolic...
8.
Zempo H, Kim S, Fuku N, Nishida Y, Higaki Y, Wan J, et al.
Aging (Albany NY)
. 2021 Jan;
13(2):1692-1717.
PMID: 33468709
Type 2 Diabetes (T2D) is an emerging public health problem in Asia. Although ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the functional effects of the...
9.
Moore T, Zhou Z, Strumwasser A, Cohn W, Lin A, Cory K, et al.
Aging Cell
. 2020 Oct;
19(11):e13166.
PMID: 33049094
Mitochondrial dysfunction is frequently associated with impairment in metabolic homeostasis and insulin action, and is thought to underlie cellular aging. However, it is unclear whether mitochondrial dysfunction is a cause...
10.
Hevener A, Ribas V, Moore T, Zhou Z
Trends Mol Med
. 2020 Oct;
27(1):31-46.
PMID: 33020031
Decrements in metabolic health elevate disease risk, including type 2 diabetes, heart disease, and certain cancers. Thus, treatment strategies to combat metabolic dysfunction are needed. Reduced ESR1 (estrogen receptor, ERα)...