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Orian S Shirihai

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Articles 146
Citations 12924
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Recent Articles
11.
Zeng J, Martin A, Han X, Shirihai O, Grinstaff M
Ind Eng Chem Res . 2024 Apr; 58(31):13910-13917. PMID: 38576774
Exposure of mitochondrial parkinsonian neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) to PC-12 cells results in significant cell death, decreases lysosomal acidity, and inhibits autophagic flux. Biodegradable poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs)...
12.
Bansal R, Torres M, Hunt M, Wang N, Chatzopoulou M, Manchanda M, et al.
JCI Insight . 2024 Apr; 9(9). PMID: 38564292
Central for wound healing is the formation of granulation tissue, which largely consists of collagen and whose importance stretches past wound healing, including being implicated in both fibrosis and skin...
13.
Mosharov E, Rosenberg A, Monzel A, Osto C, Stiles L, Rosoklija G, et al.
Res Sq . 2024 Apr; PMID: 38562777
Mitochondrial oxidative phosphorylation (OxPhos) powers brain activity, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders, underscoring the need to define the brain's molecular energetic landscape. To bridge the...
14.
Mosharov E, Rosenberg A, Monzel A, Osto C, Stiles L, Rosoklija G, et al.
bioRxiv . 2024 Mar; PMID: 38496679
Mitochondrial oxidative phosphorylation (OxPhos) powers brain activity, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders, underscoring the need to define the brain's molecular energetic landscape. To bridge the...
15.
Wortham M, Ramms B, Zeng C, Benthuysen J, Sai S, Pollow D, et al.
bioRxiv . 2024 Mar; PMID: 38464227
Selective and controlled expansion of endogenous β-cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β-cell proliferation to avoid excessive β-cell...
16.
Acevedo A, Jones A, Danna B, Turner R, Montales K, Beninca C, et al.
J Biol Chem . 2024 Feb; 300(3):105702. PMID: 38301896
Elevated levels of branched chain amino acids (BCAAs) and branched-chain α-ketoacids are associated with cardiovascular and metabolic disease, but the molecular mechanisms underlying a putative causal relationship remain unclear. The...
17.
Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie S, et al.
Redox Biol . 2024 Jan; 70:103052. PMID: 38290384
Acute liver failure caused by alcoholic hepatitis (AH) is only effectively treated with liver transplantation. Livers of patients with AH show a unique molecular signature characterized by defective hepatocellular redox...
18.
Brownstein A, Veliova M, Acin-Perez R, Villalobos F, Petcherski A, Tombolato A, et al.
Life Sci Alliance . 2023 Dec; 7(2). PMID: 38056907
Recent studies in brown adipose tissue (BAT) described a unique subpopulation of mitochondria bound to lipid droplets (LDs), which were termed PeriDroplet Mitochondria (PDM). PDM can be isolated from BAT...
19.
Saggese P, Pandey A, Alcaraz Jr M, Fung E, Hall A, Yanagawa J, et al.
Cancer Res . 2023 Nov; 84(2):305-327. PMID: 37934116
Significance: Epigenetic adaptation allows cancer cells to overcome the tumor-suppressive effects of glucose restriction by inducing dedifferentiation and an aggressive phenotype, which could help design better metabolic treatments.
20.
Palermo A, Li S, Hoeve J, Chellappa A, Morris A, Dillon B, et al.
Commun Biol . 2023 Nov; 6(1):1115. PMID: 37923961
The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate...