Olli T Pentikainen
Overview
Explore the profile of Olli T Pentikainen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
78
Citations
1081
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ali A, Li L, Courtney M, Pentikainen O, Postila P
Brief Bioinform
. 2024 Sep;
25(6).
PMID: 39311700
De novo mutations in the synaptic GTPase activating protein (SynGAP) are associated with neurological disorders like intellectual disability, epilepsy, and autism. SynGAP is also implicated in Alzheimer's disease and cancer....
2.
Moyano-Gomez P, Lehtonen J, Pentikainen O, Postila P
J Cheminform
. 2024 Aug;
16(1):97.
PMID: 39123240
The performance of molecular docking can be improved by comparing the shape similarity of the flexibly sampled poses against the target proteins' inverted binding cavities. The effectiveness of these pseudo-ligands...
3.
Jokinen E, Niemelainen M, Kurkinen S, Lehtonen J, Latti S, Postila P, et al.
Molecules
. 2023 Apr;
28(8).
PMID: 37110655
Molecular docking is a key method used in virtual screening (VS) campaigns to identify small-molecule ligands for drug discovery targets. While docking provides a tangible way to understand and predict...
4.
Kurkinen S, Lehtonen J, Pentikainen O, Postila P
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35887220
Despite the pivotal role of molecular docking in modern drug discovery, the default docking scoring functions often fail to recognize active ligands in virtual screening campaigns. Negative image-based rescoring improves...
5.
Malolepsza J, Marchwicka A, Serwa R, Niinivehmas S, Pentikainen O, Gendaszewska-Darmach E, et al.
J Enzyme Inhib Med Chem
. 2022 Mar;
37(1):940-951.
PMID: 35354390
Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT inhibitors are believed to...
6.
Jayaraj J, Jothimani M, Palanisamy C, Pentikainen O, Pannipara M, Al-Sehemi A, et al.
Bioinorg Chem Appl
. 2022 Mar;
2022:8635054.
PMID: 35340421
COVID-19 is more virulent and challenging to human life. In India, the Ministry of AYUSH recommended some strategies through Siddha, homeopathy, and other methods to effectively manage COVID-19 (Guidelines for...
7.
Kurkinen S, Lehtonen J, Pentikainen O, Postila P
J Chem Inf Model
. 2022 Feb;
62(4):1100-1112.
PMID: 35133138
Molecular docking is a key in silico method used routinely in modern drug discovery projects. Although docking provides high-quality ligand binding predictions, it regularly fails to separate the active compounds...
8.
Latti S, Niinivehmas S, Pentikainen O
J Chem Inf Model
. 2021 Dec;
62(1):9-15.
PMID: 34932340
Projects in chemo- and bioinformatics often consist of scattered data in various types and are difficult to access in a meaningful way for efficient data analysis. Data is usually too...
9.
Pathania S, Pentikainen O, Singh P
Biochim Biophys Acta Rev Cancer
. 2021 Oct;
1876(2):188631.
PMID: 34606974
Receptor tyrosine kinases play an important role in many cellular processes, and their dysregulation leads to diseases, most importantly cancer. One such receptor tyrosine kinase is c-Kit, a type-III receptor...
10.
Niinivehmas S, Pentikainen O
Molecules
. 2021 Sep;
26(17).
PMID: 34500576
Steroid hormones play an essential role in a wide variety of actions in the body, such as in metabolism, inflammation, initiating and maintaining sexual differentiation and reproduction, immune functions, and...