Florian Grebien
Overview
Explore the profile of Florian Grebien including associated specialties, affiliations and a list of published articles.
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Articles
79
Citations
2107
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Recent Articles
1.
Tarullo M, Fernandez Rodriguez G, Iaiza A, Venezia S, Macone A, Incocciati A, et al.
ACS Pharmacol Transl Sci
. 2024 Dec;
7(12):4096-4111.
PMID: 39698280
FTO, an -methyladenosine (mA) and ,2'--dimethyladenosine (mA) RNA demethylase, is a promising target for treating acute myeloid leukemia (AML) due to the significant anticancer activity of its inhibitors in preclinical...
2.
Poloske D, Sorger H, Schonbichler A, de Araujo E, Neubauer H, Orlova A, et al.
Hemasphere
. 2024 Dec;
8(12):e70001.
PMID: 39619245
The transcription factors STAT3, STAT5A, and STAT5B steer hematopoiesis and immunity, but their enhanced expression and activation promote acute myeloid leukemia (AML) or natural killer/T cell lymphoma (NKCL). Current therapeutic...
3.
Dick L, Batista P, Zaby P, Manhart G, Kopatz V, Kogler L, et al.
Sci Rep
. 2024 Oct;
14(1):25853.
PMID: 39468142
Micro- and nanoplastics can interact with various biologically active compounds forming aggregates of which the effects have yet to be understood. To this end, it is vital to characterize these...
4.
Rasouli M, Troester S, Grebien F, Goemans B, Zwaan C, Heidenreich O
Hemasphere
. 2024 Sep;
8(9):e70013.
PMID: 39323480
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a heterogeneous molecular landscape. In the pediatric context, the gene is a frequent target of chromosomal rearrangements that are linked...
5.
Kodali S, Proietti L, Valcarcel G, Lopez-Rubio A, Pessina P, Eder T, et al.
Nat Cell Biol
. 2024 Aug;
26(10):1745-1758.
PMID: 39169219
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through...
6.
Beikbaghban T, Proietti L, Ebner J, Sango R, Rattei T, Weichhart T, et al.
Biochim Biophys Acta Bioenerg
. 2024 Jul;
1865(4):149486.
PMID: 38986826
The persistent growth of cancer cells is underscored by complex metabolic reprogramming, with mitochondria playing a key role in the transition to aerobic glycolysis and representing new therapeutic targets. Mitochondrial...
7.
Edtmayer S, Witalisz-Siepracka A, Zdarsky B, Heindl K, Weiss S, Eder T, et al.
Cell Death Dis
. 2024 May;
15(5):369.
PMID: 38806478
Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in two distinct alternatively spliced isoforms, the full-length isoform STAT3α...
8.
Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman M, et al.
J Clin Invest
. 2024 Apr;
134(8).
PMID: 38618957
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation...
9.
Heyes E, Wilhelmson A, Wenzel A, Manhart G, Eder T, Schuster M, et al.
Nat Commun
. 2023 Oct;
14(1):6185.
PMID: 37794021
The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPA), promoting expression of the...
10.
Ebner J, Schmoellerl J, Piontek M, Manhart G, Troester S, Carter B, et al.
Nat Commun
. 2023 Sep;
14(1):5709.
PMID: 37726279
The BCL-2 inhibitor Venetoclax is a promising agent for the treatment of acute myeloid leukemia (AML). However, many patients are refractory to Venetoclax, and resistance develops quickly. ATP-binding cassette (ABC)...