Oleg Denisenko
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Explore the profile of Oleg Denisenko including associated specialties, affiliations and a list of published articles.
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37
Citations
1207
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Recent Articles
11.
Bomsztyk K, Mar D, Wang Y, Denisenko O, Ware C, Frazar C, et al.
Nucleic Acids Res
. 2019 Mar;
47(12):e69.
PMID: 30927002
Chromatin immunoprecipitation (ChIP) is the most widely used approach for identification of genome-associated proteins and their modifications. We have previously introduced a microplate-based ChIP platform, Matrix ChIP, where the entire...
12.
Sharifian R, Okamura D, Denisenko O, Zager R, Johnson A, Gharib S, et al.
Sci Rep
. 2018 Dec;
8(1):17870.
PMID: 30552397
Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states. Although changes in gene expression patterns have...
13.
Rahman N, Schulz V, Wang L, Gallagher P, Denisenko O, Gualdrini F, et al.
Blood Adv
. 2018 Oct;
2(20):2691-2703.
PMID: 30337297
Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds DNA at CArG (CC[A/T]GG) domains in association with myocardin-family proteins (eg, myocardin-related transcription factor A [MRTFA]) or the...
14.
Denisenko O, Mar D, Trawczynski M, Bomsztyk K
Aging (Albany NY)
. 2018 May;
10(5):1133-1145.
PMID: 29846172
Dysregulation of gene expression is a hallmark of aging. We examined epigenetic mechanisms that mediate aberrant expression of laminin genes in aging rat kidneys. In old animals, no alterations were...
15.
Bomsztyk K, Denisenko O, Wang Y
Kidney Int
. 2018 May;
93(6):1272-1275.
PMID: 29792271
Environmental factors drive epigenetic programming. DNA methylation is the best studied modification transmitting epigenetic information. A study by Qiu et al. examined potential epigenetic roots for the decline of renal...
16.
Fleming T, Eckert J, Denisenko O
Adv Exp Med Biol
. 2017 Sep;
1014:87-105.
PMID: 28864986
The early preimplantation embryo has been rigorously studied for decades to understand inherent reproductive and developmental mechanisms driving its morphogenesis from before fertilisation through to and beyond implantation. Recent research...
17.
Denisenko O, Lucas E, Sun C, Watkins A, Mar D, Bomsztyk K, et al.
Biochim Biophys Acta
. 2016 Apr;
1859(7):906-13.
PMID: 27060415
Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined...
18.
Gharib S, Mar D, Bomsztyk K, Denisenko O, Dhanireddy S, Liles W, et al.
Shock
. 2015 Nov;
45(2):148-56.
PMID: 26536201
Sepsis-induced multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in critically ill patients and remains impervious to most therapeutic interventions. We utilized a clinically relevant...
19.
Mar D, Gharib S, Zager R, Johnson A, Denisenko O, Bomsztyk K
Kidney Int
. 2015 Jun;
88(4):734-44.
PMID: 26061546
Aberrant gene expression is a molecular hallmark of acute kidney injury (AKI). As epigenetic processes control gene expression in a cell- and environment-defined manner, understanding the epigenetic pathways that regulate...
20.
Bomsztyk K, Mar D, An D, Sharifian R, Mikula M, Gharib S, et al.
Crit Care
. 2015 May;
19:225.
PMID: 25959381
Introduction: The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during...