DNA Methylation Yields Epigenetic Clues into the Diabetic Nephropathy of Pima Indians

Overview

Journal Kidney Int

Publisher Elsevier

Specialty Nephrology

Date 2018 May 25

PMID 29792271

Citations 5

Authors

Karol Bomsztyk

Oleg Denisenko

Yuliang Wang

Affiliations

Soon will be listed here.

Abstract

Environmental factors drive epigenetic programming. DNA methylation is the best studied modification transmitting epigenetic information. A study by Qiu et al. examined potential epigenetic roots for the decline of renal function in Pima Indians. A genomewide survey of blood leukocytes uncovered differentially methylated DNA sites in regulatory regions of genes associated with chronic kidney disease. This longitudinal study provides the first clues on epigenetic links between environmental factors and a high prevalence of diabetic kidney disease in Pima Indians.

Citing Articles

Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease.

Liebisch M, Wolf G Glomerular Dis. 2024; 4(1):211-226.

PMID: 39649441 PMC: 11623970. DOI: 10.1159/000541923.

Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney.

Jiang Y, Deng G, Liu C, Tang H, Zheng J, Kong X Clin Epigenetics. 2024; 16(1):1.

PMID: 38167534 PMC: 10763145. DOI: 10.1186/s13148-023-01620-8.

Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease.

Martinez-Moreno J, Fontecha-Barriuso M, Martin-Sanchez D, Guerrero-Mauvecin J, Goma-Garces E, Fernandez-Fernandez B Int J Mol Sci. 2020; 21(11).

PMID: 32526941 PMC: 7312774. DOI: 10.3390/ijms21114113.

Abnormal DNA methylation patterns in patients with infection‑caused leukocytopenia based on methylation microarrays.

Wu C, Muhataer X, Wang W, Deng M, Jin R, Lian Z Mol Med Rep. 2020; 21(6):2335-2348.

PMID: 32323775 PMC: 7185277. DOI: 10.3892/mmr.2020.11061.

Diabetic kidney diseases revisited: A new perspective for a new era.

Fu H, Liu S, Bastacky S, Wang X, Tian X, Zhou D Mol Metab. 2019; 30:250-263.

PMID: 31767176 PMC: 6838932. DOI: 10.1016/j.molmet.2019.10.005.