Norio Murai
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Explore the profile of Norio Murai including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
214
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Recent Articles
1.
Kaburagi Y, Kira K, Yahata K, Iso K, Sato Y, Matsuura F, et al.
Org Lett
. 2024 Jan;
26(14):2837-2842.
PMID: 38252895
E7130 is a novel drug candidate with an exceedingly complex chemical structure of the halichondrin class, discovered by a total synthesis approach through joint research between the Kishi group at...
2.
Tsukamoto S, Sugi N, Nishibata K, Nakazawa Y, Ito D, Fukushima S, et al.
Mol Cancer Ther
. 2022 Oct;
22(1):12-24.
PMID: 36279567
Innate and adaptive resistance to cancer therapies, such as chemotherapies, molecularly targeted therapies, and immune-modulating therapies, is a major issue in clinical practice. Subpopulations of tumor cells expressing the receptor...
3.
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine derivatives as novel selective Axl inhibitors
Inoue S, Yamane Y, Tsukamoto S, Murai N, Azuma H, Nagao S, et al.
Bioorg Med Chem Lett
. 2021 Jul;
48:128247.
PMID: 34271070
Axl and Mer are members of the TAM (Tyro3-Axl-Mer) family of receptor tyrosine kinases. Previously, we reported that enzyme-mediated inhibition of Mer by an Axl/Mer dual inhibitor led to retinal...
4.
Inoue S, Yamane Y, Tsukamoto S, Azuma H, Nagao S, Murai N, et al.
Bioorg Med Chem
. 2021 Apr;
39:116137.
PMID: 33930844
Axl and Mer are a members of the TAM (Tyro3-Axl-Mer) family of receptor tyrosine kinases, which, when activated, can promote tumor cell survival, proliferation, migration, invasion, angiogenesis, and tumor-host interactions....
5.
Tabata Y, Murai N, Sasaki T, Taniguchi S, Suzuki S, Yamazaki K, et al.
J Biomol Screen
. 2015 Aug;
20(9):1074-83.
PMID: 26245650
Stem cell research has been progressing rapidly, contributing to regenerative biology and regenerative medicine. In this field, small-molecule compounds affecting stem cell proliferation/differentiation have been explored to understand stem cell...
6.
Murai N, Miyano M, Yonaga M, Tanaka K
Org Lett
. 2012 May;
14(11):2818-21.
PMID: 22591586
A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki-Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.
7.
Murai N, Yonaga M, Tanaka K
Org Lett
. 2012 Feb;
14(5):1278-81.
PMID: 22320424
Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.
8.
Miyazaki M, Horii T, Hata K, Watanabe N, Nakamoto K, Tanaka K, et al.
Antimicrob Agents Chemother
. 2011 Aug;
55(10):4652-8.
PMID: 21825291
E1210 is a new antifungal compound with a novel mechanism of action and broad spectrum of antifungal activity. We investigated the in vitro antifungal activities of E1210 compared to those...
9.
Hata K, Horii T, Miyazaki M, Watanabe N, Okubo M, Sonoda J, et al.
Antimicrob Agents Chemother
. 2011 Jul;
55(10):4543-51.
PMID: 21788462
E1210 is a first-in-class, broad-spectrum antifungal with a novel mechanism of action-inhibition of fungal glycosylphosphatidylinositol biosynthesis. In this study, the efficacies of E1210 and reference antifungals were evaluated in murine...
10.
Nakamoto K, Tsukada I, Tanaka K, Matsukura M, Haneda T, Inoue S, et al.
Bioorg Med Chem Lett
. 2010 Jun;
20(15):4624-6.
PMID: 20573507
Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus...