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Synthesis and Evaluation of Novel Antifungal Agents-quinoline and Pyridine Amide Derivatives

Overview
Specialty Biochemistry
Date 2010 Jun 25
PMID 20573507
Citations 17
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Abstract

Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.

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