Noriko Saito-Tarashima
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Explore the profile of Noriko Saito-Tarashima including associated specialties, affiliations and a list of published articles.
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24
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55
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Recent Articles
1.
Endo Y, Itoh K, Kan-No H, Wakamatsu H, Natori Y, Saito Y, et al.
J Org Chem
. 2025 Jan;
90(5):2008-2021.
PMID: 39865870
Nucleoside derivatives having a 4-substituent show promise as potential antiviral agents as well as nucleoside units for constructing nucleic acid medicines. To develop new nucleosides, it is crucial to achieve...
2.
Kurosawa M, Kato F, Hishiki T, Ito S, Fujisawa H, Yamaguchi T, et al.
Int J Mol Sci
. 2024 Feb;
25(4).
PMID: 38396699
Dengue virus (DENV) causes dengue fever and dengue hemorrhagic fever, and DENV infection kills 20,000 people annually worldwide. Therefore, the development of anti-DENV drugs is urgently needed. Sofosbuvir (SOF) is...
3.
Saito-Tarashima N, Kagotani Y, Inoue S, Kinoshita M, Minakawa N
Curr Protoc
. 2023 Sep;
3(9):e892.
PMID: 37725690
Cyclic diadenosine monophosphate (c-di-AMP) is a bacterial cyclic dinucleotide (CDN) comprising two adenosine monophosphates covalently linked by two 3',5'-phosphodiester bonds. c-di-AMP works as a second messenger, regulating many biological processes...
4.
Nogi Y, Saito-Tarashima N, Karanjit S, Minakawa N
Molecules
. 2023 Apr;
28(7).
PMID: 37050028
5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate (ZMP) is a central intermediate in de novo purine nucleotide biosynthesis. Its nucleobase moiety, 5-aminoimidazole-4-carboxamide (Z-base), is considered an ambiguous base that can pair with any canonical base...
5.
Yu J, Kim J, Chandra G, Saito-Tarashima N, Nogi Y, Ota M, et al.
Bioorg Med Chem Lett
. 2023 Feb;
83:129172.
PMID: 36746352
As technologies using RNA or DNA have been developed, various chemical modifications of nucleosides have been attempted to increase the stability of oligonucleotides. Since it is known that 2'-OMe-modification greatly...
6.
Motani K, Saito-Tarashima N, Nishino K, Yamauchi S, Minakawa N, Kosako H
Cell Rep
. 2022 Dec;
41(12):111868.
PMID: 36543137
STING, an endoplasmic reticulum (ER)-resident receptor for cyclic di-nucleotides (CDNs), is essential for innate immune responses. Upon CDN binding, STING moves from the ER to the Golgi, where it activates...
7.
Ota M, Takahashi H, Nogi Y, Kagotani Y, Saito-Tarashima N, Kondo J, et al.
Bioorg Med Chem
. 2022 Nov;
76:117093.
PMID: 36434923
A large number of chemically modified oligonucleotides (ONs) have been developed for RNA-based technologies. In most modified RNAs, the characteristic 2'-hydroxyl (2'-OH) groups are removed to enhance both nuclease resistance...
8.
Saito-Tarashima N, Ueno M, Murai A, Matsuo A, Minakawa N
Org Biomol Chem
. 2022 Jun;
20(26):5245-5248.
PMID: 35726625
CRISPR-Cas9-mediated DNA editing relies on guide RNAs (gRNAs) that direct site-specific DNA cleavage by the Cas endonuclease. Because natural gRNA is susceptible to intracellular degradation, it is desirable to chemically...
9.
Saito-Tarashima N, Murai A, Minakawa N
Chem Pharm Bull (Tokyo)
. 2022 May;
70(5):310-315.
PMID: 35491185
DNA and RNA are ubiquitous molecules responsible for storage and transmission of genetic information and together comprise the central dogma of molecular biology. However, the recent emergence of synthetic genetic...
10.
Nakamura M, Uemura K, Saito-Tarashima N, Sato A, Orba Y, Sawa H, et al.
Chem Pharm Bull (Tokyo)
. 2021 Dec;
70(3):220-225.
PMID: 34955490
We previously showed that 5-ethynyl-(1-β-D-ribofuranosyl)imidazole-4-carboxamide (1; EICAR) is a potent anti-dengue virus (DENV) compound but is cytotoxic to some cell lines, while its 4-thio derivative, 5-ethynyl-(4-thio-1-β-D-ribofuranosyl)imidazole-4-carboxamide (2; 4'-thioEICAR), has less...