Niroshika Keppetipola
Overview
Explore the profile of Niroshika Keppetipola including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
300
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0
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Recent Articles
1.
Truong A, Barton M, Tran U, Mellody M, Berger D, Madory D, et al.
J Biol Chem
. 2024 Feb;
300(3):105733.
PMID: 38336291
RNA Binding Proteins regulate, in part, alternative pre-mRNA splicing and, in turn, gene expression patterns. Polypyrimidine tract binding proteins PTBP1 and PTBP2 are paralogous RNA binding proteins sharing 74% amino...
2.
Keppetipola N, Patchen T
J Microbiol Biol Educ
. 2021 May;
22(1).
PMID: 33953811
Although many science education researchers have investigated developing science education at the K-12 levels to meet the needs of underrepresented students in science, far fewer have considered how shifts to...
3.
Pimentel C, Le C, Tuttobene M, Subils T, Martinez J, Sieira R, et al.
Pathogens
. 2021 Apr;
10(4).
PMID: 33924559
is a nosocomial pathogen capable of causing serious infections associated with high rates of morbidity and mortality. Due to its antimicrobial drug resistance profile, is categorized as an urgent priority...
4.
Martinez A, Espinosa B, Adamek R, Thomas B, Chau J, Gonzalez E, et al.
Eur J Med Chem
. 2018 Sep;
157:1202-1213.
PMID: 30193218
The West Nile virus (WNV) has spread throughout the world causing neuroinvasive diseases with no treatments available. The viral NS2B-NS3 protease is essential for WNV survival and replication in host...
5.
Keppetipola N, Sharma S, Li Q, Black D
Crit Rev Biochem Mol Biol
. 2012 Jun;
47(4):360-78.
PMID: 22655688
Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an...
6.
Keppetipola N, Jain R, Meineke B, Diver M, Shuman S
RNA
. 2009 Apr;
15(6):1036-44.
PMID: 19383764
tRNA anticodon damage inflicted by secreted ribotoxins such as Kluyveromyces lactis gamma-toxin and bacterial colicins underlies a rudimentary innate immune system that distinguishes self from nonself species. The intracellular expression...
7.
Keppetipola N, Shuman S
J Biol Chem
. 2008 Sep;
283(45):30942-9.
PMID: 18757371
Binuclear metallophosphoesterases are an enzyme superfamily defined by a shared fold and a conserved active site. Although many family members have been characterized biochemically or structurally, the physiological substrates are...
8.
Keppetipola N, Shuman S
Nucleic Acids Res
. 2007 Nov;
35(22):7721-32.
PMID: 17986465
Clostridium thermocellum polynucleotide kinase-phosphatase (CthPnkp) catalyzes 5' and 3' end-healing reactions that prepare broken RNA termini for sealing by RNA ligase. The central phosphatase domain of CthPnkp belongs to the...
9.
Keppetipola N, Nandakumar J, Shuman S
Nucleic Acids Res
. 2007 May;
35(11):3624-30.
PMID: 17488852
Programmed RNA breakage is an emerging theme underlying cellular responses to stress, virus infection and defense against foreign species. In many cases, site-specific cleavage of the target RNA generates 2',3'...
10.
Keppetipola N, Jain R, Shuman S
J Biol Chem
. 2007 Feb;
282(16):11941-9.
PMID: 17303560
Triphosphate tunnel metalloenzymes (TTMs) are a newly recognized superfamily of phosphotransferases defined by a unique active site residing within an eight-stranded beta barrel. The prototypical members are the eukaryal metal-dependent...