Niroshika Keppetipola
Overview
Explore the profile of Niroshika Keppetipola including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
300
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Recent Articles
11.
Keppetipola N, Shuman S
J Biol Chem
. 2006 May;
281(28):19251-9.
PMID: 16675457
The central phosphatase domain of Clostridium thermocellum polynucleotide kinase/phosphatase (CthPnkp) belongs to the dinuclear metallophosphoesterase superfamily. Prior mutational studies of CthPnkp identified 7 individual active site side chains (Asp-187, His-189,...
12.
Mechanism of the phosphatase component of Clostridium thermocellum polynucleotide kinase-phosphatase
Keppetipola N, Shuman S
RNA
. 2005 Nov;
12(1):73-82.
PMID: 16301605
Polynucleotide kinase-phosphatase (Pnkp) from Clostridium thermocellum catalyzes ATP-dependent phosphorylation of 5'-OH termini of DNA or RNA polynucleotides and Ni(2+)/Mn(2+)-dependent dephosphorylation of 2',3' cyclic phosphate, 2'-phosphate, and 3'-phosphate ribonucleotides. CthPnkp is...
13.
Keppetipola N, Shuman S
J Bacteriol
. 2005 Oct;
187(20):6902-8.
PMID: 16199559
Archaea encode a DNA ligase composed of a C-terminal catalytic domain typical of ATP-dependent ligases plus an N-terminal domain similar to that found in eukaryotic cellular and poxvirus DNA ligases....