Nils Grabole
Overview
Explore the profile of Nils Grabole including associated specialties, affiliations and a list of published articles.
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7
Citations
559
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Recent Articles
1.
Egli J, Schmucki R, Loos B, Reichl S, Grabole N, Roller A, et al.
Immunogenetics
. 2018 Dec;
71(2):123-136.
PMID: 30564855
Safety and efficacy of therapeutic antibodies are often dependent on their interaction with Fc receptors for IgG (FcγRs). The Göttingen minipig represents a valuable species for biomedical research but its...
2.
Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model
Grabole N, Zhang J, Aigner S, Ruderisch N, Costa V, Weber F, et al.
Genome Med
. 2016 Sep;
8(1):94.
PMID: 27655340
Background: Tuberous sclerosis complex (TSC) is a genetic disease characterized by benign tumor growths in multiple organs and neurological symptoms induced by mTOR hyperfunction. Because the molecular pathology is highly...
3.
Le Bin G, Munoz-Descalzo S, Kurowski A, Leitch H, Lou X, Mansfield W, et al.
Development
. 2014 Feb;
141(5):1001-10.
PMID: 24504341
The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the ectopic differentiation...
4.
Grabole N, Tischler J, Hackett J, Kim S, Tang F, Leitch H, et al.
EMBO Rep
. 2013 May;
14(7):629-37.
PMID: 23670199
Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome and the pluripotency network...
5.
Leitch H, McEwen K, Turp A, Encheva V, Carroll T, Grabole N, et al.
Nat Struct Mol Biol
. 2013 Feb;
20(3):311-6.
PMID: 23416945
Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively. We investigated whether differences exist between ESCs...
6.
Magnusdottir E, Gillich A, Grabole N, Surani M
Curr Opin Genet Dev
. 2012 Jul;
22(5):466-74.
PMID: 22795169
Development of mammalian primordial germ cells (PGCs) presents a unique example of a cell fate specification event that is intimately linked with epigenetic reprogramming. Cell fate commitment is governed by...
7.
Gillich A, Bao S, Grabole N, Hayashi K, Trotter M, Pasque V, et al.
Cell Stem Cell
. 2012 Apr;
10(4):425-39.
PMID: 22482507
Epigenetic reprogramming in early germ cells is critical toward the establishment of totipotency, but investigations of the germline events are intractable. An objective cell culture-based system could provide mechanistic insight...