M Azim Surani
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Explore the profile of M Azim Surani including associated specialties, affiliations and a list of published articles.
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149
Citations
13111
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Recent Articles
1.
Wu B, Neupane J, Zhou Y, Zhang J, Chen Y, Surani M, et al.
Sci China Life Sci
. 2025 Feb;
PMID: 39969747
How a mammalian fertilized egg acquires totipotency and develops into a full-term offspring is a fundamental scientific question. Human embryonic development is difficult to study due to limited resources, technical...
2.
Roidor C, Syx L, Beyne E, Raynaud P, Zielinski D, Teissandier A, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39838109
Random X-chromosome inactivation is a hallmark of female mammalian somatic cells. This epigenetic mechanism, mediated by the long noncoding RNA Xist, occurs in the early embryo and is stably maintained...
3.
Lee S, Pierson Smela M, Surani M
Open Biol
. 2025 Jan;
15(1):240214.
PMID: 39837498
Primordial germ cells (PGCs) are the founder cells that develop into mature gametes. PGCs emerge during weeks 2-3 of human embryo development. Pluripotency genes are reactivated during PGC specification, including...
4.
Lee S, Surani M
Exp Mol Med
. 2024 Dec;
56(12):2578-2587.
PMID: 39672813
Primordial germ cells (PGCs) are the precursors of sperm and eggs. They undergo genome-wide epigenetic reprogramming to erase epigenetic memory and reset the genomic potential for totipotency. Global DNA methylation...
5.
Ito T, Kubiura-Ichimaru M, Miura F, Tajima S, Surani M, Ito T, et al.
Genes Cells
. 2024 May;
29(7):549-566.
PMID: 38811355
DNA methyltransferases and Ten-Eleven Translocation (TET) proteins regulate the DNA methylation and demethylation cycles during mouse embryonic development. Although DNMT1 mainly plays a role in the maintenance of DNA methylation...
6.
Irie N, Kobayashi T, Surani M
Methods Mol Biol
. 2024 Feb;
2770:87-97.
PMID: 38351448
Human primordial germ cell (PGC) development initiates about 2 weeks after fertilization during embryogenesis. Unique molecular events follow, including epigenetic resetting, to establish functional gametes (egg and sperm). Due to...
7.
Alves-Lopes J, Wong F, Surani M
Nat Protoc
. 2024 Feb;
19(4):1149-1182.
PMID: 38302732
Human primordial germ cells (hPGCs), the precursors of eggs and sperm, start their complex development shortly after specification and during their migration to the primitive gonads. Here, we describe protocols...
8.
Irie N, Lee S, Lorenzi V, Xu H, Chen J, Inoue M, et al.
Nat Cell Biol
. 2023 Sep;
25(10):1439-1452.
PMID: 37709822
Germline commitment following primordial germ cell (PGC) specification during early human development establishes an epigenetic programme and competence for gametogenesis. Here we follow the progression of nascent PGC-like cells derived...
9.
Castillo-Venzor A, Penfold C, Morgan M, Tang W, Kobayashi T, Wong F, et al.
Life Sci Alliance
. 2023 May;
6(8).
PMID: 37217306
Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. Although direct studies are hindered, here, we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro...
10.
Zhang J, Zhao L, Fu Y, Liu F, Wang Z, Li Y, et al.
Biol Reprod
. 2023 Apr;
108(6):887-901.
PMID: 37040346
The mule is the interspecific hybrid of horse and donkey and has hybrid vigor in muscular endurance, disease resistance, and longevity over its parents. Here, we examined adult fibroblasts of...