Nigel Yarlett
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Explore the profile of Nigel Yarlett including associated specialties, affiliations and a list of published articles.
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40
Citations
580
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Recent Articles
1.
Yarlett N, Jarroll E, Morada M, Lloyd D
Adv Microb Physiol
. 2024 May;
84:243-307.
PMID: 38821633
Organelles are membrane bound structures that compartmentalize biochemical and molecular functions. With improved molecular, biochemical and microscopy tools the diversity and function of protistan organelles has increased in recent years,...
2.
Yarlett N, Morada M, Schaefer D, Ackman K, Carranza E, de Paula Baptista R, et al.
PLoS Pathog
. 2024 Feb;
20(2):e1011992.
PMID: 38416794
Recent advances in the in vitro cultivation of Cryptosporidium parvum using hollow fiber bioreactor technology (HFB) have permitted continuous growth of parasites that complete all life cycle stages. The method...
3.
Lloyd D, Chapman A, Ellis J, Hillman K, Paget T, Yarlett N, et al.
Adv Microb Physiol
. 2021 Nov;
79:163-240.
PMID: 34836611
Publications abound on the physiology, biochemistry and molecular biology of "anaerobic" protozoal parasites as usually grown under "anaerobic" culture conditions. The media routinely used are poised at low redox potentials...
4.
Yarlett N, Morada M
Bio Protoc
. 2021 Aug;
8(15):e2947.
PMID: 34395759
Continuous growth of has proved difficult and conventional culture techniques result in short-term (2-5 days) growth of the parasite resulting in thin-walled oocysts that fail to propagate using cultures, and...
5.
Yarlett N, Morada M, Gobin M, Van Voorhis W, Arnold S
Methods Mol Biol
. 2019 Aug;
2052:335-350.
PMID: 31452171
Hollow fiber technology is a powerful tool for the culture of difficult-to-grow cells. Cryptosporidium parvum has a multistage sexual and asexual life cycle that has proved difficult to culture by...
6.
Arnold S, Choi R, Hulverson M, Whitman G, McCloskey M, Dorr C, et al.
J Infect Dis
. 2019 Jun;
220(7):1188-1198.
PMID: 31180118
Recent studies have illustrated the burden Cryptosporidium infection places on the lives of malnourished children and immunocompromised individuals. Treatment options remain limited, and efforts to develop a new therapeutic are...
7.
El Bissati K, Redel H, Ting L, Lykins J, McPhillie M, Upadhya R, et al.
Front Cell Infect Microbiol
. 2019 Mar;
9:9.
PMID: 30838177
Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite and . Four lead compounds from...
8.
Thompson A, Marshall A, Maes L, Yarlett N, Bacchi C, Gaukel E, et al.
Bioorg Med Chem Lett
. 2017 Dec;
28(2):207-213.
PMID: 29191556
A 900 compound nitroimidazole-based library derived from our pretomanid backup program with TB Alliance was screened for utility against human African trypanosomiasis (HAT) by the Drugs for Neglected Diseases initiative....
9.
Korosh T, Bujans E, Morada M, Karaalioglu C, Vanden Eynde J, Mayence A, et al.
Chem Biol Drug Des
. 2017 Mar;
90(4):489-495.
PMID: 28296056
A bisoxyphenylene-bisbenzimidazole series with increasing aliphatic chain length (CH to C H ) containing a meta- (m) or para (p)-benzimidazole linkage to the phenylene ring was tested for ability to...
10.
Vanden Eynde J, Mayence A, Mottamal M, Bacchi C, Yarlett N, Kaiser M, et al.
Pharmaceuticals (Basel)
. 2016 Apr;
9(2).
PMID: 27104545
A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b. rhodesiense, Trypanosoma cruzi, Leishmania donovani...