Nigel S Scrutton
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Explore the profile of Nigel S Scrutton including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Liu M, Ma W, Su X, Zhang X, Lu Y, Zhang S, et al.
Cell Rep
. 2022 Dec;
41(10):111758.
PMID: 36476857
The heme branch of tetrapyrrole biosynthesis contributes to the regulation of chlorophyll levels. However, the mechanism underlying the balance between chlorophyll and heme synthesis remains elusive. Here, we identify a...
22.
Scrutton N, Fujimori D
Curr Opin Struct Biol
. 2022 Nov;
77:102499.
PMID: 36371847
No abstract available.
23.
Park H, Toogood H, Chen G, Scrutton N
Microb Biotechnol
. 2022 Nov;
16(2):307-321.
PMID: 36353812
Halomonas bluephagenesis TD1.0 was engineered to produce the biofuel propane, bioplastic poly-3-hydroxybutyrate (PHB), and biochemicals mandelate and hydroxymandelate in a single, semi-continuous batch fermentation under non-sterile conditions. Multi-product separation was...
24.
Taylor A, Heyes D, Scrutton N
Curr Opin Struct Biol
. 2022 Nov;
77:102491.
PMID: 36323132
Photoenzymes use light to initiate biochemical reactions. Although rarely found in nature, their study has advanced understanding of how light energy can be harnessed to facilitate enzyme catalysis, which is...
25.
Whitehead J, Leferink N, Komati Reddy G, Levy C, Hay S, Takano E, et al.
ACS Catal
. 2022 Oct;
12(19):12123-12131.
PMID: 36249875
Terpenes are the largest class of natural products and are attractive targets in the fuel, fragrance, pharmaceutical, and flavor industries. Harvesting terpenes from natural sources is environmentally intensive and often...
26.
Stewart A, Shanmugam M, Kutta R, Scrutton N, Lovett J, Hay S
Biochemistry
. 2022 Aug;
61(17):1735-1742.
PMID: 35979922
Calmodulin (CaM) is a highly dynamic Ca-binding protein that exhibits large conformational changes upon binding Ca and target proteins. Although it is accepted that CaM exists in an equilibrium of...
27.
Russell M, Currin A, Rowe W, Chen G, Barran P, Scrutton N
Sci Data
. 2022 Aug;
9(1):492.
PMID: 35963929
Despite its greener credentials, biomanufacturing remains financially uncompetitive compared with the higher carbon emitting, hydrocarbon-based chemical industry. Replacing traditional chassis such as E. coli with novel robust organisms, are a...
28.
Hedison T, Iorgu A, Calabrese D, Heyes D, Shanmugam M, Scrutton N
J Phys Chem Lett
. 2022 Jul;
13(30):6927-6934.
PMID: 35867774
Copper nitrite reductases (CuNiRs) catalyze the reduction of nitrite to form nitric oxide. In recent years, new classes of redox partner linked CuNiRs have been isolated and characterized by crystallographic...
29.
Rose S, Baba S, Okumura H, Antonyuk S, Sasaki D, Hedison T, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2205664119.
PMID: 35862453
Many enzymes utilize redox-coupled centers for performing catalysis where these centers are used to control and regulate the transfer of electrons required for catalysis, whose untimely delivery can lead to...
30.
Green L, Scrutton N, Currin A
Methods Mol Biol
. 2022 Jun;
2461:111-122.
PMID: 35727446
Directed evolution is a powerful tool for the rapid improvement of a target protein toward a desired fitness criteria, such as activity, specificity, or stability. In order to achieve these...