Nigel S Scrutton
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Explore the profile of Nigel S Scrutton including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Kumar V, Agrawal D, Bommareddy R, Islam M, Jacob S, Balan V, et al.
Crit Rev Biotechnol
. 2023 Nov;
44(6):1103-1120.
PMID: 37932016
The circular economy is anticipated to bring a disruptive transformation in manufacturing technologies. Robust and industrial scalable microbial strains that can simultaneously assimilate and valorize multiple carbon substrates are highly...
12.
Whitehead J, Leferink N, Johannissen L, Hay S, Scrutton N
ACS Catal
. 2023 Oct;
13(19):12774-12802.
PMID: 37822860
The review by Christianson, published in 2017 on the twentieth anniversary of the emergence of the field, summarizes the foundational discoveries and key advances in terpene synthase/cyclase (TS) biocatalysis (Christianson,...
13.
Faulkner M, Hoeven R, Kelly P, Sun Y, Park H, Liu L, et al.
Biotechnol Biofuels Bioprod
. 2023 Oct;
16(1):152.
PMID: 37821908
Background: Production of relatively low value, bulk commodity chemicals and fuels by microbial species requires a step-change in approach to decrease the capital and operational costs associated with scaled fermentation....
14.
Yu Y, Rue Casamajo A, Finnigan W, Schnepel C, Barker R, Morrill C, et al.
ACS Catal
. 2023 Sep;
13(18):12310-12321.
PMID: 37736118
Biocatalysis is important in the discovery, development, and manufacture of pharmaceuticals. However, the identification of enzymes for target transformations of interest requires major screening efforts. Here, we report a structure-based...
15.
Zhao J, Zhuo Y, Diaz D, Shanmugam M, Telfer A, Lindley P, et al.
J Am Chem Soc
. 2023 Sep;
145(37):20672-20682.
PMID: 37688545
Oxygenase and peroxygenase enzymes generate intermediates at their active sites which bring about the controlled functionalization of inert C-H bonds in substrates, such as in the enzymatic conversion of methane...
16.
Poddar H, Rios-Santacruz R, Heyes D, Shanmugam M, Brookfield A, Johannissen L, et al.
Nat Commun
. 2023 Aug;
14(1):5082.
PMID: 37604813
CarH is a coenzyme B-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here,...
17.
Biosynthesis of cannabigerol and cannabigerolic acid: the gateways to further cannabinoid production
Kearsey L, Yan C, Prandi N, Toogood H, Takano E, Scrutton N
Synth Biol (Oxf)
. 2023 Jun;
8(1):ysad010.
PMID: 37323510
Cannabinoids are a therapeutically valuable class of secondary metabolites with a vast number of substituents. The native cannabinoid biosynthetic pathway of generates cannabigerolic acid (CBGA), the common substrate to multiple...
18.
Scrutton N
FEBS J
. 2023 May;
290(9):2204-2207.
PMID: 37132524
The study of enzymes never disappoints. Despite its long history-almost 150 years following the first documented use of the word enzyme in 1878-the field of enzymology advances apace. This long...
19.
Speirs M, Hardman S, Iorgu A, Johannissen L, Heyes D, Scrutton N, et al.
J Phys Chem Lett
. 2023 Mar;
14(13):3236-3242.
PMID: 36972502
Recent reports have described the use of ene-reductase flavoenzymes to catalyze non-natural photochemical reactions. These studies have focused on using reduced flavoenzyme, yet oxidized flavins have superior light harvesting properties....
20.
Barker R, Yu Y, De Maria L, Johannissen L, Scrutton N
ACS Catal
. 2022 Dec;
12(24):15352-15360.
PMID: 36570077
To rationally engineer the substrate scope and selectivity of flavin-dependent halogenases (FDHs), it is essential to first understand the reaction mechanism and substrate interactions in the active site. FDHs have...