Michael J Sutcliffe
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Explore the profile of Michael J Sutcliffe including associated specialties, affiliations and a list of published articles.
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77
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1185
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Recent Articles
1.
Pang J, Scrutton N, Sutcliffe M
Chemistry
. 2014 Jul;
20(36):11390-401.
PMID: 25048616
A computational study was performed on the experimentally elusive cyclisation step in the cofactor pyridoxal 5'-phosphate (PLP)-dependent D-ornithine 4,5-aminomutase (OAM)-catalysed reaction. Calculations using both model systems and a combined quantum...
2.
Hay S, Johannissen L, Hothi P, Sutcliffe M, Scrutton N
J Am Chem Soc
. 2012 May;
134(23):9749-54.
PMID: 22632111
The rate and kinetic isotope effect (KIE) on proton transfer during the aromatic amine dehydrogenase-catalyzed reaction with phenylethylamine shows complex pressure and temperature dependences. We are able to rationalize these...
3.
Pang J, Li X, Morokuma K, Scrutton N, Sutcliffe M
J Am Chem Soc
. 2012 Jan;
134(4):2367-77.
PMID: 22239442
We present here an energetic and atomistic description of how D-ornithine 4,5-aminomutase (OAM), an adenosylcobalamin (AdoCbl; coenzyme B(12))-dependent isomerase, employs a large-scale protein domain conformational change to orchestrate the homolytic...
4.
Ivanova E, Pang J, Jowitt T, Yan G, Warwicker J, Sutcliffe M, et al.
Proteins
. 2011 Nov;
80(2):602-15.
PMID: 22095685
Protein-protein interaction is a fundamental process in all major biological processes. The hexameric Tim9-Tim10 (translocase of inner membrane) complex of the mitochondrial intermembrane space plays an essential chaperone-like role during...
5.
Johannissen L, Scrutton N, Sutcliffe M
Angew Chem Int Ed Engl
. 2011 Feb;
50(9):2129-32.
PMID: 21344567
No abstract available.
6.
Stevenson B, Bibby J, Pignatelli P, Muangnoicharoen S, ONeill P, Lian L, et al.
Insect Biochem Mol Biol
. 2011 Feb;
41(7):492-502.
PMID: 21324359
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated detoxification is an important resistance mechanism. CYP6M2 is over-expressed in...
7.
Hay S, Pudney C, Sutcliffe M, Scrutton N
J Phys Org Chem
. 2010 Oct;
23(7):696-701.
PMID: 20890464
We report the first study of the effects of hydrostatic pressure on α-2° KIEs for an enzyme-catalysed H-transfer reaction that occurs by 'deep' tunnelling. High pressure causes a significant decrease...
8.
Niazi U, Bibby J, Sutcliffe M
J Recept Signal Transduct Res
. 2010 Sep;
31(1):53-65.
PMID: 20822478
The innate immune system uses inflammation to respond to infection of humans by various parasitic organisms and in some individuals can produce a hyperinflammatory response to infection by the human...
9.
Pudney C, Johannissen L, Sutcliffe M, Hay S, Scrutton N
J Am Chem Soc
. 2010 Aug;
132(32):11329-35.
PMID: 20698699
The role of dynamical effects in enzyme catalysis is both complex and widely debated. Understanding how dynamics can influence the barrier to an enzyme catalyzed reaction requires the development of...
10.
Williamson M, Sutcliffe M
Biochem Soc Trans
. 2010 Jul;
38(4):875-8.
PMID: 20658969
In the present article, we describe the two standard high-throughput methods for identification of protein complexes: two-hybrid screens and TAP (tandem affinity purification) tagging. These methods have been used to...