Nicolle A Rosa-Mercado
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Explore the profile of Nicolle A Rosa-Mercado including associated specialties, affiliations and a list of published articles.
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6
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111
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Recent Articles
1.
Huang Z, Diehl F, Wang M, Li Y, Song A, Chen F, et al.
Mol Cell
. 2025 Feb;
85(4):802-814.e12.
PMID: 39947183
Cells tightly regulate ribosome homeostasis to adapt to changing environments. Ribosomes are degraded during stress, but the mechanisms responsible remain unclear. Here, we show that starvation induces the selective depletion...
2.
Rosa-Mercado N, Buskirk A, Green R
RNA
. 2024 Sep;
30(12):1572-1585.
PMID: 39293933
Translation elongation inhibitors are commonly used to study different cellular processes. Yet, their specific impact on transcription and mRNA decay has not been thoroughly assessed. Here, we use TimeLapse sequencing...
3.
Zimmer J, Rosa-Mercado N, Canzio D, Steitz J, Simon M
Mol Cell
. 2021 Sep;
81(21):4398-4412.e7.
PMID: 34520723
Despite the critical regulatory function of promoter-proximal pausing, the influence of pausing kinetics on transcriptional control remains an active area of investigation. Here, we present Start-TimeLapse-seq (STL-seq), a method that...
4.
Rosa-Mercado N, Steitz J
Trends Biochem Sci
. 2021 Sep;
47(3):206-217.
PMID: 34489151
Readthrough transcription caused by inefficient 3'-end cleavage of nascent mRNAs has emerged as a hallmark of the mammalian cellular stress response and results in the production of long noncoding RNAs...
5.
Rosa-Mercado N, Zimmer J, Apostolidi M, Rinehart J, Simon M, Steitz J
Mol Cell
. 2021 Jan;
81(3):502-513.e4.
PMID: 33400923
Stress-induced readthrough transcription results in the synthesis of downstream-of-gene (DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular stress remain unknown. Nascent transcription profiles during DoG induction in human cell...
6.
Withers J, Mondol V, Pawlica P, Rosa-Mercado N, Tycowski K, Ghasempur S, et al.
Annu Rev Virol
. 2019 May;
6(1):297-317.
PMID: 31039329
Like their host cells, many viruses express noncoding RNAs (ncRNAs). Despite the technical challenge of ascribing function to ncRNAs, diverse biological roles for virally expressed ncRNAs have been described, including...
7.
Rosa-Mercado N, Withers J, Steitz J
Genes Dev
. 2017 Jun;
31(10):957-958.
PMID: 28637691
Post-transcriptional modification of RNA nucleosides has been implicated as a pivotal regulator of mRNA biology. In this issue of , Ke and colleagues (pp. 990-1006) provide insights into the temporal...