Joshua T Zimmer
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Explore the profile of Joshua T Zimmer including associated specialties, affiliations and a list of published articles.
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10
Citations
127
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Recent Articles
1.
Boddu P, Gupta A, Roy R, de la Pena Avalos B, Olazabal-Herrero A, Neuenkirchen N, et al.
Mol Cell
. 2024 Mar;
84(8):1475-1495.e18.
PMID: 38521065
Transcription and splicing of pre-messenger RNA are closely coordinated, but how this functional coupling is disrupted in human diseases remains unexplored. Using isogenic cell lines, patient samples, and a mutant...
2.
Gao Y, Zimmer J, Vasic R, Liu C, Gbyli R, Zheng S, et al.
Cell Rep
. 2023 Sep;
42(10):113163.
PMID: 37742191
N-methyladenosine (mA) RNA modification controls numerous cellular processes. To what extent these post-transcriptional regulatory mechanisms play a role in hematopoiesis has not been fully elucidated. We here show that the...
3.
Lu-Culligan W, Connor L, Xie Y, Ekundayo B, Rose B, Machyna M, et al.
Nature
. 2023 Sep;
622(7981):173-179.
PMID: 37731000
Lysine residues in histones and other proteins can be modified by post-translational modifications that encode regulatory information. Lysine acetylation and methylation are especially important for regulating chromatin and gene expression....
4.
Zimmer J, Vock I, Schofield J, Kiefer L, Moon M, Simon M
bioRxiv
. 2023 Jun;
PMID: 37292657
RNA metabolic labeling using 4-thiouridine (sU) captures the dynamics of RNA synthesis and decay. The power of this approach is dependent on appropriate quantification of labeled and unlabeled sequencing reads,...
5.
Swartzel J, Bond M, Pintado-Urbanc A, Daftary M, Krone M, Douglas T, et al.
ACS Chem Biol
. 2022 Jun;
17(7):1789-1798.
PMID: 35749470
The RNA decapping scavenger protein, DcpS, has recently been identified as a dependency in acute myeloid leukemia (AML). The potent DcpS inhibitor RG3039 attenuates AML cell viability, and shRNA knockdown...
6.
Winkler L, Jimenez M, Zimmer J, Williams A, Simon M, Dimitrova N
Cell Rep
. 2022 Apr;
39(3):110687.
PMID: 35443176
The p53-induced long noncoding RNA (lncRNA) lincRNA-p21 is proposed to act in cis to promote p53-dependent expression of the neighboring cell cycle gene, Cdkn1a/p21. The molecular mechanism through which the...
7.
Biancon G, Joshi P, Zimmer J, Hunck T, Gao Y, Lessard M, et al.
Mol Cell
. 2022 Mar;
82(6):1107-1122.e7.
PMID: 35303483
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer...
8.
Zimmer J, Rosa-Mercado N, Canzio D, Steitz J, Simon M
Mol Cell
. 2021 Sep;
81(21):4398-4412.e7.
PMID: 34520723
Despite the critical regulatory function of promoter-proximal pausing, the influence of pausing kinetics on transcriptional control remains an active area of investigation. Here, we present Start-TimeLapse-seq (STL-seq), a method that...
9.
Rosa-Mercado N, Zimmer J, Apostolidi M, Rinehart J, Simon M, Steitz J
Mol Cell
. 2021 Jan;
81(3):502-513.e4.
PMID: 33400923
Stress-induced readthrough transcription results in the synthesis of downstream-of-gene (DoG)-containing transcripts. The mechanisms underlying DoG formation during cellular stress remain unknown. Nascent transcription profiles during DoG induction in human cell...
10.
Carmody M, Zimmer J, Cushman C, Nguyen T, Lawson T
Virus Res
. 2018 May;
252:48-57.
PMID: 29782878
Many viruses make use of, and even direct, the ubiquitin-proteasome system to facilitate the generation of a cellular environment favorable for virus replication, while host cells use selected protein ubiquitylation...