Daniele Canzio
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Explore the profile of Daniele Canzio including associated specialties, affiliations and a list of published articles.
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16
Citations
1350
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Recent Articles
1.
Kiefer L, Gaudin S, Rajkumar S, Servito G, Langen J, Mui M, et al.
Science
. 2024 Jul;
385(6707):eadm9802.
PMID: 39052779
Expression of Protocadherin (Pcdh) genes is critical to the generation of neuron identity and wiring of the nervous system. Pcdhα genes are arranged in clusters and exhibit a range of...
2.
Kiefer L, Chiosso A, Langen J, Buckley A, Gaudin S, Rajkumar S, et al.
Science
. 2023 Jun;
380(6651):eadf8440.
PMID: 37347873
Neural type-specific expression of clustered Protocadherin (Pcdh) proteins is essential for the establishment of connectivity patterns during brain development. In mammals, deterministic expression of the same Pcdh isoform promotes minimal...
3.
Zimmer J, Rosa-Mercado N, Canzio D, Steitz J, Simon M
Mol Cell
. 2021 Sep;
81(21):4398-4412.e7.
PMID: 34520723
Despite the critical regulatory function of promoter-proximal pausing, the influence of pausing kinetics on transcriptional control remains an active area of investigation. Here, we present Start-TimeLapse-seq (STL-seq), a method that...
4.
Gerbino V, Kaunga E, Ye J, Canzio D, OKeeffe S, Rudnick N, et al.
Neuron
. 2020 Mar;
106(5):789-805.e5.
PMID: 32220666
DNA sequence variants in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS). Here we show that mice bearing human ALS-associated TBK1 missense loss-of-function mutations,...
5.
Canzio D, Maniatis T
Curr Opin Neurobiol
. 2019 Nov;
59:213-220.
PMID: 31710891
The assembly of functional neural circuits in vertebrate organisms requires complex mechanisms of self-recognition and self-avoidance. Neurites (axons and dendrites) from the same neuron recognize and avoid self, but engage...
6.
Vega-Benedetti A, Loi E, Moi L, Blois S, Fadda A, Antonelli M, et al.
Clin Epigenetics
. 2019 Jul;
11(1):100.
PMID: 31288858
Background: Clustered protocadherins (PCDHs) map in tandem at human chromosome 5q31 and comprise three multi-genes clusters: α-, β- and γ-PCDH. The expression of this cluster consists of a complex mechanism...
7.
Canzio D, Nwakeze C, Horta A, Rajkumar S, Coffey E, Duffy E, et al.
Cell
. 2019 Apr;
177(3):639-653.e15.
PMID: 30955885
Stochastic activation of clustered Protocadherin (Pcdh) α, β, and γ genes generates a cell-surface identity code in individual neurons that functions in neural circuit assembly. Here, we show that Pcdhα...
8.
Mountoufaris G, Canzio D, Nwakeze C, Chen W, Maniatis T
Annu Rev Cell Dev Biol
. 2018 Oct;
34:471-493.
PMID: 30296392
The ability of neurites of individual neurons to distinguish between themselves and neurites from other neurons and to avoid self (self-avoidance) plays a key role in neural circuit assembly in...
9.
Duffy E, Canzio D, Maniatis T, Simon M
Nucleic Acids Res
. 2018 Jul;
46(14):6996-7005.
PMID: 29986098
Here, we describe an approach to enrich newly transcribed RNAs from primary mouse neurons using 4-thiouridine (s4U) metabolic labeling and solid phase chemistry. This one-step enrichment procedure captures s4U-RNA by...
10.
Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin D, et al.
Cell
. 2015 Aug;
162(4):900-10.
PMID: 26276636
CTCF and the associated cohesin complex play a central role in insulator function and higher-order chromatin organization of mammalian genomes. Recent studies identified a correlation between the orientation of CTCF-binding...