Nicole Hoebers
Overview
Explore the profile of Nicole Hoebers including associated specialties, affiliations and a list of published articles.
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12
Citations
154
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Recent Articles
1.
Lempesis I, Hoebers N, Essers Y, Jocken J, Dubois L, Blaak E, et al.
J Clin Endocrinol Metab
. 2024 Feb;
109(12):e2291-e2301.
PMID: 38375937
Context: Abdominal obesity is associated with increased cardiometabolic disease risk, while lower body fat seems to confer protection against obesity-related complications. The functional differences between upper and lower body adipose...
2.
Lempesis I, Hoebers N, Essers Y, Jocken J, Dineen R, Blaak E, et al.
Front Endocrinol (Lausanne)
. 2023 Jul;
14:1205799.
PMID: 37455922
Introduction: Upper and lower body fat accumulation poses an opposing obesity-related cardiometabolic disease risk. Depot-differences in subcutaneous adipose tissue (SAT) function may underlie these associations. We aimed to investigate the...
3.
Lempesis I, Hoebers N, Essers Y, Jocken J, Rouschop K, Blaak E, et al.
Cells
. 2022 Nov;
11(22).
PMID: 36428961
Adipose tissue (AT) inflammation may increase obesity-related cardiometabolic complications. Altered AT oxygen partial pressure (pO) may impact the adipocyte inflammatory phenotype. Here, we investigated the effects of pO levels on...
4.
de Ligt M, Hesselink M, Jorgensen J, Hoebers N, Blaak E, Goossens G
Adipocyte
. 2021 Aug;
10(1):408-411.
PMID: 34402717
Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive...
5.
van Meijel R, Vogel M, Jocken J, Vliex L, Smeets J, Hoebers N, et al.
Mol Metab
. 2021 Jul;
53:101287.
PMID: 34224918
Objective: Recent studies suggest that hypoxia exposure may improve glucose homeostasis, but well-controlled human studies are lacking. We hypothesized that mild intermittent hypoxia (MIH) exposure decreases tissue oxygen partial pressure...
6.
Vogel M, Jocken J, Sell H, Hoebers N, Essers Y, Rouschop K, et al.
J Clin Endocrinol Metab
. 2018 Jul;
103(10):3688-3697.
PMID: 30020463
Context And Objectives: Upper and lower body adipose tissue (AT) exhibits opposing associations with obesity-related cardiometabolic diseases. Recent studies have suggested that altered AT oxygen tension (pO2) may contribute to...
7.
Verboven K, Hansen D, Moro C, Eijnde B, Hoebers N, Knol J, et al.
Clin Sci (Lond)
. 2016 Apr;
130(13):1105-14.
PMID: 27129190
Catecholamines and atrial natriuretic peptide (ANP) are major regulators of adipocyte lipolysis. Although obesity is characterized by catecholamine resistance in subcutaneous adipose tissue (SCAT), data on ANP lipolytic response and...
8.
Dirkx E, van Eys G, Schwenk R, Steinbusch L, Hoebers N, Coumans W, et al.
J Mol Cell Cardiol
. 2014 Sep;
76:208-17.
PMID: 25173922
In the insulin resistant heart, energy fuel selection shifts away from glucose utilization towards almost complete dependence on long-chain fatty acids (LCFA). This shift results in excessive cardiac lipid accumulation...
9.
Angin Y, Schwenk R, Nergiz-Unal R, Hoebers N, Heemskerk J, Kuijpers M, et al.
Am J Physiol Endocrinol Metab
. 2014 Jun;
307(2):E225-36.
PMID: 24895286
Activation of AMP-activated protein kinase (AMPK) in cardiomyocytes induces translocation of glucose transporter GLUT4 and long-chain fatty acid (LCFA) transporter CD36 from endosomal stores to the sarcolemma to enhance glucose...
10.
Schwenk R, Angin Y, Steinbusch L, Dirkx E, Hoebers N, Coumans W, et al.
J Biol Chem
. 2012 Sep;
287(44):37530-9.
PMID: 22936810
Cardiac glucose utilization is regulated by reversible translocation of the glucose transporter GLUT4 from intracellular stores to the plasma membrane. During the onset of diet-induced insulin resistance, elevated lipid levels...