Resveratrol Supplementation Reduces ACE2 Expression in Human Adipose Tissue

Overview

Journal Adipocyte

Specialties Cell Biology
Endocrinology
Physiology

Date 2021 Aug 17

PMID 34402717

Citations 25

Authors

Marlies de Ligt

Matthijs K C Hesselink

Johanna Jorgensen

Nicole Hoebers

Ellen E Blaak

Gijs H Goossens

Affiliations

Soon will be listed here.

Abstract

Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking. Here, we investigated the effects of 30-days resveratrol supplementation on RAS components in AT and skeletal muscle in men with obesity in a placebo-controlled cross-over study. Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components. These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19.

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References

Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong J, Turner A . Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2. Circ Res. 2020; 126(10):1456-1474. PMC: 7188049. DOI: 10.1161/CIRCRESAHA.120.317015. View

Ryan P, Caplice N . Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?. Obesity (Silver Spring). 2020; 28(7):1191-1194. PMC: 7264526. DOI: 10.1002/oby.22843. View

Tiao M, Lin Y, Yu H, Sheen J, Lin I, Lai Y . Resveratrol ameliorates maternal and post-weaning high-fat diet-induced nonalcoholic fatty liver disease via renin-angiotensin system. Lipids Health Dis. 2018; 17(1):178. PMC: 6064630. DOI: 10.1186/s12944-018-0824-3. View

Konings E, Timmers S, Boekschoten M, Goossens G, Jocken J, Afman L . The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. Int J Obes (Lond). 2013; 38(3):470-3. DOI: 10.1038/ijo.2013.155. View

Goossens G, Blaak E, van Baak M . Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders. Obes Rev. 2003; 4(1):43-55. DOI: 10.1046/j.1467-789x.2003.00091.x. View

Kim E, Kim M, Lim J, Kim Y, Shin S, Park C . The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. Atherosclerosis. 2018; 270:123-131. DOI: 10.1016/j.atherosclerosis.2018.01.043. View

Goossens G, Dicker D, Farpour-Lambert N, Fruhbeck G, Mullerova D, Woodward E . Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity. Obes Facts. 2020; 13(4):439-452. PMC: 7490508. DOI: 10.1159/000510719. View

Li W, Moore M, Vasilieva N, Sui J, Wong S, Berne M . Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426(6965):450-4. PMC: 7095016. DOI: 10.1038/nature02145. View

van der Voort P, Moser J, Zandstra D, Muller Kobold A, Knoester M, Calkhoven C . Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon. 2020; 6(8):e04696. PMC: 7439829. DOI: 10.1016/j.heliyon.2020.e04696. View

10.

Andrade J, Paraiso A, Garcia Z, Ferreira A, Sinisterra R, Sousa F . Cross talk between angiotensin-(1-7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice. Peptides. 2014; 55:158-65. DOI: 10.1016/j.peptides.2014.03.006. View

11.

Timmers S, Konings E, Bilet L, Houtkooper R, van de Weijer T, Goossens G . Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011; 14(5):612-22. PMC: 3880862. DOI: 10.1016/j.cmet.2011.10.002. View

12.

Livak K, Schmittgen T . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2002; 25(4):402-8. DOI: 10.1006/meth.2001.1262. View

13.

Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J . Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020; 63(3):364-374. PMC: 7088566. DOI: 10.1007/s11427-020-1643-8. View

14.

Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B . A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005; 11(8):875-9. PMC: 7095783. DOI: 10.1038/nm1267. View

15.

Moran C, Biros E, Krishna S, Wang Y, Tikellis C, Morton S . Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2. Arterioscler Thromb Vasc Biol. 2017; 37(11):2195-2203. DOI: 10.1161/ATVBAHA.117.310129. View