Will A Coumans
Overview
Explore the profile of Will A Coumans including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
26
Citations
603
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Geraets I, Coumans W, Strzelecka A, Schonleitner P, Antoons G, Schianchi F, et al.
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33807195
(1) Background: The exact mechanism(s) underlying pathological changes in a heart in transition to hypertrophy and failure are not yet fully understood. However, alterations in cardiac energy metabolism seem to...
2.
Luiken J, Neumann D, Glatz J, Coumans W, Chanda D, Nabben M
Methods Mol Biol
. 2018 Feb;
1732:343-361.
PMID: 29480486
Here we describe an assay for simultaneous measurement of cellular uptake rates of long-chain fatty acids (LCFA) and glucose that can be applied to cells in suspension. The uptake assay...
3.
Mansor L, Sousa Fialho M, Yea G, Coumans W, West J, Kerr M, et al.
Cardiovasc Res
. 2017 Apr;
113(7):737-748.
PMID: 28419197
Aims: The type 2 diabetic heart oxidizes more fat and less glucose, which can impair metabolic flexibility and function. Increased sarcolemmal fatty acid translocase (FAT/CD36) imports more fatty acid into...
4.
Liu Y, Steinbusch L, Nabben M, Kapsokalyvas D, van Zandvoort M, Schonleitner P, et al.
Diabetes
. 2017 Mar;
66(6):1521-1534.
PMID: 28302654
Dietary fat overconsumption leads to myocardial lipid accumulation through mechanisms that are incompletely resolved. Previously, we identified increased translocation of the fatty acid transporter CD36 from its endosomal storage compartment...
5.
Rodriguez-Calvo R, Chanda D, Oligschlaeger Y, Miglianico M, Coumans W, Barroso E, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2017 Feb;
1862(5):541-551.
PMID: 28214558
Small heterodimer partner (SHP) is an atypical nuclear receptor expressed in heart that has been shown to inhibit the hypertrophic response. Here, we assessed the role of SHP in cardiac...
6.
Oligschlaeger Y, Miglianico M, Dahlmans V, Rubio-Villena C, Chanda D, Garcia-Gimeno M, et al.
Biochem J
. 2016 Feb;
473(7):937-47.
PMID: 26831516
AMP-activated protein kinase (AMPK) is a metabolic stress-sensing kinase. We previously showed that glucose deprivation induces autophosphorylation of AMPKβ at Thr-148, which prevents the binding of AMPK to glycogen. Furthermore,...
7.
Franekova V, Angin Y, Hoebers N, Coumans W, Simons P, Glatz J, et al.
Am J Physiol Cell Physiol
. 2014 Dec;
308(4):C297-307.
PMID: 25472960
Insulin resistance is an important risk factor for the development of several cardiac pathologies, thus advocating strategies for restoring insulin sensitivity of the heart in these conditions. Omega-3 polyunsaturated fatty...
8.
Dirkx E, van Eys G, Schwenk R, Steinbusch L, Hoebers N, Coumans W, et al.
J Mol Cell Cardiol
. 2014 Sep;
76:208-17.
PMID: 25173922
In the insulin resistant heart, energy fuel selection shifts away from glucose utilization towards almost complete dependence on long-chain fatty acids (LCFA). This shift results in excessive cardiac lipid accumulation...
9.
Angin Y, Schwenk R, Nergiz-Unal R, Hoebers N, Heemskerk J, Kuijpers M, et al.
Am J Physiol Endocrinol Metab
. 2014 Jun;
307(2):E225-36.
PMID: 24895286
Activation of AMP-activated protein kinase (AMPK) in cardiomyocytes induces translocation of glucose transporter GLUT4 and long-chain fatty acid (LCFA) transporter CD36 from endosomal stores to the sarcolemma to enhance glucose...
10.
Habets D, Luiken J, Ouwens M, Coumans W, Vergouwe M, Maarbjerg S, et al.
Front Physiol
. 2012 Sep;
3:361.
PMID: 22973240
Aim: The signaling pathways involved in the regulation of cardiac GLUT4 translocation/glucose uptake and CD36 translocation/long-chain fatty acid uptake are not fully understood. We compared in heart/muscle-specific PKC-λ knockout mice...