Nicolas Gilles
Overview
Explore the profile of Nicolas Gilles including associated specialties, affiliations and a list of published articles.
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Articles
65
Citations
613
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Recent Articles
1.
Delaitre C, Boisbrun M, Acherar S, Dias A, Kleinclauss A, Achard M, et al.
J Med Chem
. 2024 Nov;
67(22):20275-20297.
PMID: 39526976
Angiotensin II (AngII) regulates cerebral circulation and binds with a similar affinity to AT and AT receptors. Biased AT agonists, such as TRV027, which are able to selectively activate β-arrestin...
2.
Stanajic-Petrovic G, Keck M, Barbe P, Urman A, Correia E, Isnard P, et al.
J Am Soc Nephrol
. 2024 Oct;
36(2):181-192.
PMID: 39431458
No abstract available.
3.
Gilles N
Biology (Basel)
. 2023 Apr;
12(4).
PMID: 37106745
The type 2 vasopressin receptor (V2R) is expressed in the kidneys, and it is the keystone of water homeostasis. Under the control of the antidiuretic hormone vasopressin, the V2R ensures...
4.
Van Baelen A, Iturrioz X, Chaigneau M, Kessler P, Llorens-Cortes C, Servent D, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768653
The renin-angiotensin system (RAS) is one of the main regulatory systems of cardiovascular homeostasis. It is mainly composed of angiotensin-converting enzyme (ACE) and angiotensin II receptors AT1 and AT2. ACE...
5.
Hanbouch L, Schaack B, Kasri A, Fontaine G, Gkanatsiou E, Brinkmalm G, et al.
Mol Neurobiol
. 2022 Sep;
59(11):7056-7073.
PMID: 36076005
Excess brain cholesterol is strongly implicated in the pathogenesis of Alzheimer's disease (AD). Here we evaluated how the presence of a cholesterol-binding site (CBS) in the transmembrane and juxtamembrane regions...
6.
Reynaud S, Laurin S, Ciolek J, Barbe P, Van Baelen A, Susset M, et al.
J Med Chem
. 2022 Sep;
65(18):12084-12094.
PMID: 36063022
The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous...
7.
Ciolek J, Zoukimian C, Dhot J, Burban M, Triquigneaux M, Lauzier B, et al.
Biomed Pharmacother
. 2022 Jun;
150:113094.
PMID: 35658242
All five muscarinic receptors have important physiological roles. The endothelial M2 and M3 subtypes regulate arterial tone through direct coupling to Gq or Gi/o proteins. Yet, we lack selective pharmacological...
8.
Van Baelen A, Robin P, Kessler P, Maiga A, Gilles N, Servent D
Front Mol Biosci
. 2022 Feb;
9:811365.
PMID: 35198603
Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in...
9.
Droctove L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, et al.
Br J Pharmacol
. 2022 Feb;
179(13):3470-3481.
PMID: 35122240
Background And Purpose: Venomous animals express numerous Kunitz-type peptides. The mambaquaretin-1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine-vasopressin V2 receptor (V2R)...
10.
Droctove L, Lancien M, Tran V, Susset M, Jego B, Theodoro F, et al.
Theranostics
. 2020 Oct;
10(25):11580-11594.
PMID: 33052234
MQ1, a snake toxin which targets with high nanomolar affinity and absolute selectivity for the type 2 vasopressin receptor (V2R), is a drug candidate for renal diseases and a molecular...