Michael Gurevitz
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Explore the profile of Michael Gurevitz including associated specialties, affiliations and a list of published articles.
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58
Citations
1044
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Recent Articles
1.
Gurevitz M, Zhorov B, Dong K
J Neurobiol Physiol
. 2023 Apr;
4(1):9-12.
PMID: 37034138
Gating of voltage-dependent sodium channels involves coordinated movements of the voltage sensors in the voltage-sensing modules (VSMs) of the four domains (DI-DIV) in response to membrane depolarization. Zhu et al....
2.
Zhu Q, Du Y, Nomura Y, Gao R, Cang Z, Wei G, et al.
Insect Biochem Mol Biol
. 2021 Aug;
137:103625.
PMID: 34358664
Scorpion α-toxins bind at the pharmacologically-defined site-3 on the sodium channel and inhibit channel inactivation by preventing the outward movement of the voltage sensor in domain IV (IVS4), whereas scorpion...
3.
Zhorov B, Du Y, Song W, Luo N, Gordon D, Gurevitz M, et al.
Biochem J
. 2021 Jul;
478(14):2843-2869.
PMID: 34195804
The interaction of insect-selective scorpion depressant β-toxins (LqhIT2 and Lqh-dprIT3 from Leiurus quinquestriatus hebraeus) with the Blattella germanica sodium channel, BgNav1-1a, was investigated using site-directed mutagenesis, electrophysiological analyses, and structural...
4.
Marcus Y, Gurevitz M
Biochem J
. 2020 Mar;
477(6):1149-1158.
PMID: 32150261
Searching for compounds that inhibit the growth of photosynthetic organisms highlighted a prominent effect at micromolar concentrations of the nitroheteroaromatic thioether, 2-nitrothiophene, applied in the light. Since similar effects were...
5.
Karbat I, Altman-Gueta H, Fine S, Szanto T, Hamer-Rogotner S, Dym O, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(37):18700-18709.
PMID: 31444298
Voltage-dependent potassium channels (Ks) gate in response to changes in electrical membrane potential by coupling a voltage-sensing module with a K-selective pore. Animal toxins targeting Ks are classified as pore...
6.
Marcus Y, Tal N, Ronen M, Carmieli R, Gurevitz M
Biochem J
. 2017 Dec;
474(24):4269.
PMID: 29242382
No abstract available.
7.
Marcus Y, Tal N, Ronen M, Carmieli R, Gurevitz M
Biochem J
. 2016 Sep;
473(23):4413-4426.
PMID: 27647935
Ornidazole of the 5-nitroimidazole drug family is used to treat protozoan and anaerobic bacterial infections via a mechanism that involves preactivation by reduction of the nitro group, and production of...
8.
Gur Barzilai M, Kahn R, Regev N, Gordon D, Moran Y, Gurevitz M
Biochem J
. 2014 Jul;
463(2):271-7.
PMID: 25055135
Av3 is a peptide neurotoxin from the sea anemone Anemonia viridis that shows specificity for arthropod voltage-gated sodium channels (Navs). Interestingly, Av3 competes with a scorpion α-toxin on binding to...
9.
Ma Z, Kong J, Gordon D, Gurevitz M, Kallen R
PLoS One
. 2013 Dec;
8(11):e77758.
PMID: 24302985
The position of the voltage-sensing transmembrane segment, S4, in voltage-gated ion channels as a function of voltage remains incompletely elucidated. Site-3 toxins bind primarily to the extracellular loops connecting transmembrane...
10.
Gur Barzilai M, Reitzel A, Kraus J, Gordon D, Technau U, Gurevitz M, et al.
Cell Rep
. 2012 Aug;
2(2):242-8.
PMID: 22854023
Ion selectivity of metazoan voltage-gated Na(+) channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity...