Gregory Upert
Overview
Explore the profile of Gregory Upert including associated specialties, affiliations and a list of published articles.
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28
Citations
365
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Recent Articles
1.
Manioglu S, Modaresi S, Thoma J, Overall S, Upert G, Luther A, et al.
Nat Commun
. 2023 Aug;
14(1):4773.
PMID: 37558675
No abstract available.
2.
Schuster M, Brabet E, Oi K, Desjonqueres N, Moehle K, Le Poupon K, et al.
Sci Adv
. 2023 May;
9(21):eadg3683.
PMID: 37224246
The rise of antimicrobial resistance poses a substantial threat to our health system, and, hence, development of drugs against novel targets is urgently needed. The natural peptide thanatin kills Gram-negative...
3.
Manioglu S, Modaresi S, Ritzmann N, Thoma J, Overall S, Harms A, et al.
Nat Commun
. 2022 Oct;
13(1):6195.
PMID: 36271003
Polymyxins are last-resort antibiotics with potent activity against multi-drug resistant pathogens. They interact with lipopolysaccharide (LPS) in bacterial membranes, but mechanistic details at the molecular level remain unclear. Here, we...
4.
Reynaud S, Laurin S, Ciolek J, Barbe P, Van Baelen A, Susset M, et al.
J Med Chem
. 2022 Sep;
65(18):12084-12094.
PMID: 36063022
The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous...
5.
Droctove L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, et al.
Br J Pharmacol
. 2022 Feb;
179(13):3470-3481.
PMID: 35122240
Background And Purpose: Venomous animals express numerous Kunitz-type peptides. The mambaquaretin-1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine-vasopressin V2 receptor (V2R)...
6.
Upert G, Luther A, Obrecht D, Ermert P
Med Drug Discov
. 2021 Jan;
9:100078.
PMID: 33398258
This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy...
7.
Reynaud S, Ciolek J, Degueldre M, Saez N, Sequeira A, Duhoo Y, et al.
J Med Chem
. 2020 Jul;
63(15):8250-8264.
PMID: 32602722
Animal venoms are rich in hundreds of toxins with extraordinary biological activities. Their exploitation is difficult due to their complexity and the small quantities of venom available from most venomous...
8.
Haler J, Massonnet P, Far J, Upert G, Gilles N, Mourier G, et al.
J Am Soc Mass Spectrom
. 2020 Apr;
31(4):990-995.
PMID: 32233380
In the past, we developed a method inferring physicochemical properties from ion mobility mass spectrometry (IM-MS) data from polydisperse synthetic homopolymers. We extend here the method to biomolecules that are...
9.
Delvaux C, Massonnet P, Kune C, Haler J, Upert G, Mourier G, et al.
Anal Chem
. 2019 Dec;
92(3):2425-2434.
PMID: 31885261
Disulfide bonds between cysteine residues are commonly involved in the stability of numerous peptides and proteins and are crucial for providing biological activities. In such peptides, the appropriate cysteine connectivity...
10.
Luther A, Urfer M, Zahn M, Muller M, Wang S, Mondal M, et al.
Nature
. 2019 Nov;
576(7786):E5.
PMID: 31758154
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.