Nicolas C Hoch
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Explore the profile of Nicolas C Hoch including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
445
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0
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Recent Articles
1.
Papp H, Toth E, Bovari-Biri J, Banfai K, Juhasz P, Mahdi M, et al.
Br J Pharmacol
. 2024 Aug;
181(23):4782-4803.
PMID: 39191429
Background And Purpose: To date, there are limited options for severe Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 virus. As ADP-ribosylation events are involved in regulating the life cycle of...
2.
Rijpkema K, Schuller M, van der Veer M, Rieken S, Chang D, Balic P, et al.
Org Lett
. 2024 Jun;
26(27):5700-5704.
PMID: 38935522
Protein adenosine diphosphate (ADP)-ribosylation is crucial for a proper immune response. Accordingly, viruses have evolved ADP-ribosyl hydrolases to remove these modifications, a prominent example being the SARS-CoV-2 NSP3 macrodomain, "Mac1"....
3.
Serrano-Benitez A, Wells S, Drummond-Clarke L, Russo L, Thomas J, Leal G, et al.
EMBO J
. 2023 Jul;
42(18):e113190.
PMID: 37492888
DNA single-strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present behind replication forks or ahead of replication forks is unclear. To...
4.
Hoch N
Physiology (Bethesda)
. 2023 May;
38(5).
PMID: 37253212
DNA is a remarkable biochemical macromolecule tasked with storing the genetic information that instructs life on planet Earth. However, its inherent chemical instability within the cellular milieu is incompatible with...
5.
di Lazzaro Filho R, Yamamoto G, Silva T, Rocha L, Linnenkamp B, Castro M, et al.
J Med Genet
. 2023 Apr;
60(11):1127-1132.
PMID: 37055165
Rothmund-Thomson syndrome (RTS) is a rare, heterogeneous autosomal recessive genodermatosis, with poikiloderma as its hallmark. It is classified into two types: type I, with biallelic variants in and juvenile cataracts,...
6.
Popovic M, Kahl V, Hoch N
Front Cell Dev Biol
. 2022 Mar;
10:868038.
PMID: 35281085
No abstract available.
7.
Hoch N
Biochem Soc Trans
. 2021 Aug;
49(4):1711-1721.
PMID: 34351418
The COVID-19 pandemic has prompted intense research efforts into elucidating mechanisms of coronavirus pathogenesis and to propose antiviral interventions. The interferon (IFN) response is the main antiviral component of human...
8.
Luscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, et al.
FEBS J
. 2021 Jul;
289(23):7399-7410.
PMID: 34323016
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in...
9.
Hoch N, Polo L
Genet Mol Biol
. 2020 Jan;
43(1 suppl 1):e20190075.
PMID: 31930280
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of...
10.
King A, Hoch N, McGregor N, Sims N, Smyth I, Heierhorst J
Hum Mol Genet
. 2019 Apr;
28(15):2573-2588.
PMID: 31009951
Mutations in subunits of the cilia-specific cytoplasmic dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result...