Keith W Caldecott
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Explore the profile of Keith W Caldecott including associated specialties, affiliations and a list of published articles.
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109
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6844
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Recent Articles
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Semenova S, Nammi D, Garrett G, Margolin G, Sinclair J, Maroofian R, et al.
bioRxiv
. 2025 Jan;
PMID: 39803460
Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in , a scaffold protein that plays a central...
3.
Hrychova K, Burdova K, Polackova Z, Giamaki D, Valtorta B, Brazina J, et al.
Nucleic Acids Res
. 2024 Aug;
52(18):10986-10998.
PMID: 39162207
In response to DNA damage, the histone PARylation factor 1 (HPF1) regulates PARP1/2 activity, facilitating serine ADP-ribosylation of chromatin-associated factors. While PARP1/2 are known for their role in DNA single-strand...
4.
Wells S, Caldecott K
DNA Repair (Amst)
. 2024 Jun;
140:103710.
PMID: 38901287
The KU heterodimer (KU70/80) is rapidly recruited to DNA double-strand breaks (DSBs) to regulate their processing and repair. Previous work has revealed that the amino-terminal von Willebrand-like (vWA-like) domain in...
5.
Meroni A, Wells S, Fonseca C, Ray Chaudhuri A, Caldecott K, Vindigni A
J Cell Biol
. 2024 Feb;
223(4).
PMID: 38315097
DNA combing and DNA spreading are two central approaches for studying DNA replication fork dynamics genome-wide at single-molecule resolution by distributing labeled genomic DNA on coverslips or slides for immunodetection....
6.
Milano L, Gautam A, Caldecott K
Mol Cell
. 2023 Dec;
84(1):70-79.
PMID: 38103560
Genome damage and transcription are intimately linked. Tens to hundreds of thousands of DNA lesions arise in each cell each day, many of which can directly or indirectly impede transcription....
7.
Caldecott K
Trends Biochem Sci
. 2023 Dec;
49(1):68-78.
PMID: 38040599
DNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient mechanisms...
8.
Thuresson A, Brazina J, Akram T, Albrecht J, Dahl N, Soussi Zander C, et al.
Mol Genet Genomic Med
. 2023 Nov;
12(1):e2295.
PMID: 37916443
Background: Microcephaly with early-onset seizures (MCSZ) is a neurodevelopmental disorder caused by pathogenic variants in the DNA strand break repair protein, polynucleotide kinase 3'-phosphatase (PNKP). Methods: We have used whole...
9.
Gautam A, Fawcett H, Burdova K, Brazina J, Caldecott K
Mol Cell
. 2023 Oct;
83(20):3669-3678.e7.
PMID: 37816354
UV irradiation induces "bulky" DNA photodimers such as (6-4)-photoproducts and cyclobutane pyrimidine dimers that are removed by nucleotide excision repair, a complex process defective in the sunlight-sensitive and cancer-prone disease...
10.
Zagnoli-Vieira G, Brazina J, Van den Bogaert K, Huybrechts W, Molenaers G, Caldecott K, et al.
Hum Genet
. 2023 Aug;
142(9):1417-1427.
PMID: 37558815
Mutations in TDP2, encoding tyrosyl-DNA phosphodiesterase 2, have been associated with a syndromal form of autosomal recessive spinocerebellar ataxia, type 23 (SCAR23). This is a very rare and progressive neurodegenerative...