Luis M Polo
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Explore the profile of Luis M Polo including associated specialties, affiliations and a list of published articles.
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7
Citations
214
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Recent Articles
1.
Ruis C, Peacock T, Polo L, Masone D, Alvarez M, Hinrichs A, et al.
Microb Genom
. 2023 May;
9(5).
PMID: 37185044
Exposure to different mutagens leaves distinct mutational patterns that can allow inference of pathogen replication niches. We therefore investigated whether SARS-CoV-2 mutational spectra might show lineage-specific differences, dependent on the...
2.
Hoch N, Polo L
Genet Mol Biol
. 2020 Jan;
43(1 suppl 1):e20190075.
PMID: 31930280
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of...
3.
Polo L, Xu Y, Hornyak P, Garces F, Zeng Z, Hailstone R, et al.
Cell Rep
. 2019 Jan;
26(3):573-581.e5.
PMID: 30650352
XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the recruitment of Polβ, LigIIIα, and end-processing factors, such as PNKP and APTX. XRCC1 itself is...
4.
Alt A, Dang H, Wells O, Polo L, Smith M, McGregor G, et al.
Nat Commun
. 2017 Jan;
8:14011.
PMID: 28134253
The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome structure-which is essential for accurate chromosome duplication and segregation. Each complex...
5.
Grundy G, Polo L, Zeng Z, Rulten S, Hoch N, Paomephan P, et al.
Nat Commun
. 2016 Aug;
7:12404.
PMID: 27530147
PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal...
6.
de Cima S, Polo L, Diez-Fernandez C, Martinez A, Cervera J, Fita I, et al.
Sci Rep
. 2015 Nov;
5:16950.
PMID: 26592762
Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here...
7.
Polo L, Castro C, Cruzado M, Collino C, Cuello-Carrion F, Ciocca D, et al.
Eur J Pharmacol
. 2006 Dec;
556(1-3):19-26.
PMID: 17134695
Modulation of vascular smooth muscle cell (VSMC) proliferation has critical therapeutic implications for vascular disease. Recently, we demonstrated that the sesquiterpene lactone dehydroleucodine (DhL) inhibited the proliferation of VSMCs in...