Nicholas P Whitehead
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Explore the profile of Nicholas P Whitehead including associated specialties, affiliations and a list of published articles.
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21
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1309
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Recent Articles
1.
Kim M, Bible K, Regnier M, Adams M, Froehner S, Whitehead N
Physiol Rep
. 2019 Mar;
7(6):e14018.
PMID: 30912308
Duchenne muscular dystrophy (DMD), caused by absence of the protein dystrophin, is a common, degenerative muscle disease affecting 1:5000 males worldwide. With recent advances in respiratory care, cardiac dysfunction now...
2.
Kim M, Whitehead N, Bible K, Adams M, Froehner S
Hum Mol Genet
. 2018 Sep;
28(3):386-395.
PMID: 30256963
Syntrophins are a family of modular adaptor proteins that are part of the dystrophin protein complex, where they recruit and anchor a variety of signaling proteins. Previously we generated mice...
3.
Whitehead N, Bible K, Kim M, Odom G, Adams M, Froehner S
J Physiol
. 2016 Aug;
594(24):7215-7227.
PMID: 27570057
Key Points: Duchenne muscular dystrophy (DMD) is a severe, degenerative muscle disease that is commonly studied using the mdx mouse. The mdx diaphragm muscle closely mimics the pathophysiological changes in...
4.
Whitehead N, Kim M, Bible K, Adams M, Froehner S
Rare Dis
. 2016 May;
4(1):e1156286.
PMID: 27141415
Duchenne muscular dystrophy (DMD) is the most common and severe inherited neuromuscular disorder. DMD is caused by mutations in the gene encoding the dystrophin protein in muscle fibers. Dystrophin was...
5.
Whitehead N
Autophagy
. 2016 Feb;
12(4):705-6.
PMID: 26890413
Autophagy has recently emerged as an important cellular process for the maintenance of skeletal muscle health and function. Excessive autophagy can trigger muscle catabolism, leading to atrophy. In contrast, reduced...
6.
Nanou E, Yan J, Whitehead N, Kim M, Froehner S, Scheuer T, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(4):1068-73.
PMID: 26755585
Facilitation and inactivation of P/Q-type calcium (Ca(2+)) currents through the regulation of voltage-gated Ca(2+) (CaV) 2.1 channels by Ca(2+) sensor (CaS) proteins contributes to the facilitation and rapid depression of...
7.
Allen D, Whitehead N, Froehner S
Physiol Rev
. 2015 Dec;
96(1):253-305.
PMID: 26676145
Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further connections via laminin to...
8.
Rebolledo D, Kim M, Whitehead N, Adams M, Froehner S
Hum Mol Genet
. 2015 Nov;
25(1):158-66.
PMID: 26604149
Nitric oxide (NO) is a key regulator of skeletal muscle function and metabolism, including vasoregulation, mitochondrial function, glucose uptake, fatigue and excitation-contraction coupling. The main generator of NO in skeletal...
9.
Whitehead N, Kim M, Bible K, Adams M, Froehner S
Proc Natl Acad Sci U S A
. 2015 Sep;
112(41):12864-9.
PMID: 26417069
Duchenne muscular dystrophy (DMD) is a lethal, degenerative muscle disease with no effective treatment. DMD muscle pathogenesis is characterized by chronic inflammation, oxidative stress, and fibrosis. Statins, cholesterol-lowering drugs, inhibit...
10.
Gamble L, Graham D, Bluestein B, Whitehead N, Hockenbery D, Morrish F, et al.
Biointerphases
. 2015 Feb;
10(1):019008.
PMID: 25708638
The ability to image cells and tissues with chemical and molecular specificity could greatly expand our understanding of biological processes. The subcellular resolution mass spectral imaging capability of time of...