Nicholas P Whitehead
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Explore the profile of Nicholas P Whitehead including associated specialties, affiliations and a list of published articles.
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21
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1309
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Recent Articles
11.
Percival J, Whitehead N, Adams M, Adamo C, Beavo J, Froehner S
J Pathol
. 2012 Jun;
228(1):77-87.
PMID: 22653783
Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy caused by mutations in the dystrophin gene. Loss of dystrophin initiates a progressive decline in skeletal muscle integrity...
12.
Zhang B, Whitehead N, Gervasio O, Reardon T, Vale M, Fatkin D, et al.
J Appl Physiol (1985)
. 2012 Mar;
112(12):2077-86.
PMID: 22461447
Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of antibody staining of cytoskeletal proteins. Extracellular Ca(2+) entry...
13.
Whitehead N, Yeung E, Froehner S, Allen D
PLoS One
. 2010 Dec;
5(12):e15354.
PMID: 21187957
Recent studies have shown that oxidative stress contributes to the pathogenesis of muscle damage in dystrophic (mdx) mice. In this study we have investigated the role of NADPH oxidase as...
14.
Allen D, Whitehead N
Int J Biochem Cell Biol
. 2010 Nov;
43(3):290-4.
PMID: 21084059
Duchenne muscular dystrophy is a severe muscle wasting disease caused by a mutation in the gene for dystrophin--a cytoskeletal protein connecting the contractile machinery to a group of proteins in...
15.
Allen D, Zhang B, Whitehead N
Adv Exp Med Biol
. 2010 Sep;
682:297-313.
PMID: 20824533
One component of stretch-induced muscle damage is an increase in the permeability of the cell membrane. As a result soluble myoplasmic proteins leak out of the muscle into the plasma,...
16.
Allen D, Gervasio O, Yeung E, Whitehead N
Can J Physiol Pharmacol
. 2010 Mar;
88(2):83-91.
PMID: 20237582
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by the absence of the cytoskeletal protein dystrophin. Experiments on the mdx mouse, a model of DMD, have shown that...
17.
Gervasio O, Whitehead N, Yeung E, Phillips W, Allen D
J Cell Sci
. 2008 Jun;
121(Pt 13):2246-55.
PMID: 18544631
Transient receptor potential canonical 1 (TRPC1), a widely expressed calcium (Ca(2+))-permeable channel, is potentially involved in the pathogenesis of Duchenne muscular dystrophy (DMD). Ca(2+) influx through stretch-activated channels, possibly formed...
18.
Whitehead N, Pham C, Gervasio O, Allen D
J Physiol
. 2008 Feb;
586(7):2003-14.
PMID: 18258657
Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by a mutation in the gene encoding dystrophin, a protein linking the cytoskeleton to the extracellular matrix. In this...
19.
Whitehead N, Streamer M, Lusambili L, Sachs F, Allen D
Neuromuscul Disord
. 2006 Sep;
16(12):845-54.
PMID: 17005404
It is well-known that muscles from mdx mice are more susceptible to membrane damage from eccentric contractions than wild-type muscles. The present study tested the hypothesis that the stretch-induced membrane...
20.
Whitehead N, Yeung E, Allen D
Clin Exp Pharmacol Physiol
. 2006 Jun;
33(7):657-62.
PMID: 16789936
1. Duchenne muscular dystrophy (DMD) is a lethal, degenerative muscle disease caused by a genetic mutation that leads to the complete absence of the cytoskeletal protein dystrophin in muscle fibres....