Nicholas J Matheson
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Explore the profile of Nicholas J Matheson including associated specialties, affiliations and a list of published articles.
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58
Citations
3273
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Recent Articles
1.
Bertlin J, Pauzaite T, Liang Q, Wit N, Williamson J, Sia J, et al.
bioRxiv
. 2024 Sep;
PMID: 39282259
Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau () tumour suppressor gene. Here, we...
2.
Fischer K, Lulla A, So T, Pereyra-Gerber P, Raybould M, Kohler T, et al.
Nat Biotechnol
. 2024 Aug;
PMID: 39143416
Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of...
3.
Krishna B, Lim E, Metaxaki M, Jackson S, Mactavous L, Lyons P, et al.
Sci Adv
. 2024 Feb;
10(8):eadi9379.
PMID: 38381822
After acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a proportion of patients experience persistent symptoms beyond 12 weeks, termed Long Covid. Understanding the mechanisms that cause this debilitating...
4.
Jackson H, Long H, Yam-Puc J, Palmulli R, Haigh T, Pereyra Gerber P, et al.
J Extracell Vesicles
. 2024 Feb;
13(2):e12412.
PMID: 38339765
The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the...
5.
Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals
Boston R, Guan R, Kalmar L, Beier S, Horner E, Beristain-Covarrubias N, et al.
Life Sci Alliance
. 2024 Feb;
7(4).
PMID: 38316462
Bidirectional interactions between the immune system and the gut microbiota are key contributors to various physiological functions. Immune-associated diseases such as cancer and autoimmunity, and efficacy of immunomodulatory therapies, have...
6.
Abbott K, Ali A, Casalena D, Do B, Ferreira R, Cheah J, et al.
Cell Chem Biol
. 2023 Sep;
30(9):1156-1168.e7.
PMID: 37689063
A challenge for screening new anticancer drugs is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a...
7.
Yam-Puc J, Hosseini Z, Horner E, Pereyra Gerber P, Beristain-Covarrubias N, Hughes R, et al.
Nat Commun
. 2023 Jun;
14(1):3292.
PMID: 37369658
Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here,...
8.
Potts M, Fletcher-Etherington A, Nightingale K, Mescia F, Bergamaschi L, Calero-Nieto F, et al.
Cell Rep
. 2023 Jun;
42(6):112613.
PMID: 37302069
Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mechanistic...
9.
Wit N, Gogola E, West J, Vornbaumen T, Seear R, Bailey P, et al.
Sci Adv
. 2023 May;
9(20):eadg2235.
PMID: 37196082
Cells produce considerable genotoxic formaldehyde from an unknown source. We carry out a genome-wide CRISPR-Cas9 genetic screen in metabolically engineered HAP1 cells that are auxotrophic for formaldehyde to find this...
10.
van der Klaauw A, Horner E, Pereyra-Gerber P, Agrawal U, Foster W, Spencer S, et al.
Nat Med
. 2023 May;
29(5):1146-1154.
PMID: 37169862
Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people...