Robin Antrobus
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Explore the profile of Robin Antrobus including associated specialties, affiliations and a list of published articles.
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104
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3855
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Recent Articles
1.
Ravenhill B, Oliveira M, Wood G, Di Y, Kite J, Wang X, et al.
Cell Rep
. 2025 Feb;
44(2):115263.
PMID: 39921859
Appropriate cellular recognition of viruses is essential for the generation of an effective innate and adaptive immune response. Viral sensors and their downstream signaling components thus provide a crucial first...
2.
Stewart A, Loudon K, Routledge M, Lee C, Trotter P, Richoz N, et al.
Sci Transl Med
. 2024 Sep;
16(766):eadh5090.
PMID: 39321268
Lower urinary tract infection (UTI) is common but only rarely complicated by pyelonephritis. However, the mechanisms preventing extension to the kidney are unclear. Here, we identified neutrophil extracellular traps (NETs)...
3.
Sandovici I, Fernandez-Twinn D, Campbell N, Cooper W, Sekita Y, Zvetkova I, et al.
Cell Rep
. 2024 Sep;
43(9):114750.
PMID: 39283743
Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and...
4.
Danac J, Matthews R, Gungi A, Qin C, Parsons H, Antrobus R, et al.
Mol Cell
. 2024 Jul;
84(15):2870-2881.e5.
PMID: 39013473
The human silencing hub (HUSH) preserves genome integrity through the epigenetic repression of invasive genetic elements. However, despite our understanding of HUSH as an obligate complex of three subunits, only...
5.
Young K, Wojdyla K, Lai T, Mulholland K, Aldaz Casanova S, Antrobus R, et al.
J Cell Sci
. 2024 Jun;
137(14).
PMID: 38904097
PTPRK is a receptor tyrosine phosphatase that is linked to the regulation of growth factor signalling and tumour suppression. It is stabilized at the plasma membrane by trans homophilic interactions...
6.
Hunter L, Kite J, Fletcher-Etherington A, Nightingale K, Nobre L, Antrobus R, et al.
J Gen Virol
. 2024 Apr;
105(4).
PMID: 38687323
The human cytomegalovirus (HCMV) pUS2 glycoprotein exploits the host's endoplasmic reticulum (ER)-associated degradation (ERAD) pathway to degrade major histocompatibility complex class I (MHC-I) and prevent antigen presentation. Beyond MHC-I, pUS2...
7.
Robinson M, Antrobus R, Sanger A, Davies A, Gershlick D
J Cell Biol
. 2024 Apr;
223(7).
PMID: 38578286
The AP-1 adaptor complex is found in all eukaryotes, but it has been implicated in different pathways in different organisms. To look directly at AP-1 function, we generated stably transduced...
8.
Li H, Fletcher-Etherington A, Hunter L, Keshri S, Fielding C, Nightingale K, et al.
Cell Host Microbe
. 2024 Mar;
32(4):466-478.e11.
PMID: 38479395
Human cytomegalovirus (HCMV) is an important human pathogen that regulates host immunity and hijacks host compartments, including lysosomes, to assemble virions. We combined a quantitative proteomic analysis of HCMV infection...
9.
Wilson E, Yu Y, Leal N, Woodward J, Patikas N, Morris J, et al.
Cell Death Dis
. 2024 Mar;
15(3):203.
PMID: 38467609
Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of...
10.
Albarnaz J, Kite J, Oliveira M, Li H, Di Y, Christensen M, et al.
Nat Commun
. 2023 Dec;
14(1):8134.
PMID: 38065956
Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis...