Nicholas J Hawkins
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Explore the profile of Nicholas J Hawkins including associated specialties, affiliations and a list of published articles.
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52
Citations
1726
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Recent Articles
1.
Millward J, He Z, Nibali A, Mouradov D, Mielke L, Tran K, et al.
J Transl Med
. 2025 Mar;
23(1):298.
PMID: 40065354
Background: The presence of tumour-infiltrating lymphocytes (TILs) is a well-established prognostic biomarker across multiple cancer types, with higher TIL counts being associated with lower recurrence rates and improved patient survival....
2.
Wagner S, Reisenbuchler D, West N, Niehues J, Zhu J, Foersch S, et al.
Cancer Cell
. 2023 Aug;
41(9):1650-1661.e4.
PMID: 37652006
Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine pathology slides in colorectal cancer (CRC). However, current approaches rely on convolutional neural networks (CNNs) and have mostly...
3.
Mouradov D, Greenfield P, Li S, In E, Storey C, Sakthianandeswaren A, et al.
Gastroenterology
. 2023 Mar;
165(1):104-120.
PMID: 36933623
Background & Aims: Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this relates to clinicomolecular characteristics and...
4.
Meagher N, Gorringe K, Wakefield M, Bolithon A, Pang C, Chiu D, et al.
Clin Cancer Res
. 2022 Oct;
28(24):5383-5395.
PMID: 36222710
Purpose: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the...
5.
Williams D, Mouradov D, Newman M, Amini E, Nickless D, Fang C, et al.
Mod Pathol
. 2020 Feb;
33(7):1420-1432.
PMID: 32047231
Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, while tumours with ≤50% mucin are designated as having a mucinous component. However, these...
6.
Jorissen R, Croxford M, Jones I, Ward R, Hawkins N, Gibbs P, et al.
Int J Cancer
. 2019 Jan;
145(1):132-142.
PMID: 30620048
Adjuvant! Online Inc (A!O), the Memorial Sloan Kettering Cancer Center (MSKCC), MD Anderson (MDA) and Mayo Clinic (MC) provide calculators to predict survival probabilities for patients with resected early-stage colon...
7.
Domingo E, Camps C, Kaisaki P, Parsons M, Mouradov D, Pentony M, et al.
Lancet Gastroenterol Hepatol
. 2018 Jul;
3(9):635-643.
PMID: 30042065
Background: Molecular indicators of colorectal cancer prognosis have been assessed in several studies, but most analyses have been restricted to a handful of markers. We aimed to identify prognostic biomarkers...
8.
Liu Q, Thoms J, Nunez A, Huang Y, Knezevic K, Packham D, et al.
Clin Cancer Res
. 2018 Jun;
24(18):4602-4611.
PMID: 29898989
is a major tumor suppressor gene involved in the pathogenesis of Lynch syndrome and various sporadic cancers. Despite their potential pathogenic importance, genomic regions capable of regulating expression over long...
9.
Sakthianandeswaren A, Parsons M, Mouradov D, MacKinnon R, Catimel B, Liu S, et al.
Cancer Discov
. 2018 Jun;
8(8):988-1005.
PMID: 29880585
ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by dedicated transferases and hydrolases. Here, we show that frequent deletions (∼30%) of the mono-ADP-ribosylhydrolase locus in...
10.
Williams D, Mouradov D, Jorissen R, Newman M, Amini E, Nickless D, et al.
Gut
. 2018 Feb;
68(3):465-474.
PMID: 29382774
Objective: Tumour-infiltrating lymphocyte (TIL) response and deficient DNA mismatch repair (dMMR) are determinants of prognosis in colorectal cancer. Although highly correlated, evidence suggests that these are independent predictors of outcome....