Nicholas J Hawkins
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Explore the profile of Nicholas J Hawkins including associated specialties, affiliations and a list of published articles.
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52
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1726
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Recent Articles
11.
Liu Q, Hesson L, Nunez A, Packham D, Hawkins N, Ward R, et al.
Cancer Genet
. 2016 Nov;
209(11):497-500.
PMID: 27886675
Lynch syndrome is a hereditary cancer syndrome caused by the autosomal dominant inheritance of loss-of-function mutations in DNA mismatch repair (MMR) genes. Approximately one quarter of clinically suspected cases have...
12.
Ma S, Henry C, Llamosas E, Higgins R, Daniels B, Hesson L, et al.
Virchows Arch
. 2016 Nov;
469(6):717.
PMID: 27796585
No abstract available.
13.
Hesson L, Ng B, Zarzour P, Srivastava S, Kwok C, Packham D, et al.
Mol Cancer Res
. 2016 Sep;
14(12):1217-1228.
PMID: 27671336
Implications: The novel genetic, epigenetic, and transcriptional changes associated with LST development reveal important insights into why some adenomas do not progress to cancer. The finding that LSTs exhibit a...
14.
Ma S, Henry C, Llamosas E, Higgins R, Daniels B, Hesson L, et al.
Virchows Arch
. 2016 Sep;
470(1):99-108.
PMID: 27631337
The Wnt signalling receptor receptor tyrosine kinase-like orphan receptor 2 (ROR2) is implicated in numerous human cancers. However, there have been conflicting reports regarding ROR2 expression, some studies showing upregulation...
15.
Ma S, Srivastava S, Llamosas E, Hawkins N, Hesson L, Ward R, et al.
BMC Cancer
. 2016 Jul;
16:508.
PMID: 27440078
Background: Colorectal cancer (CRC) is closely linked to Wnt signalling, with 94 % of cases exhibiting a Wnt related mutation. ROR2 is a receptor tyrosine kinase that is thought to...
16.
Jonnagaddala J, Croucher J, Jue T, Meagher N, Caruso L, Ward R, et al.
Stud Health Technol Inform
. 2016 Jun;
225:387-91.
PMID: 27332228
Cancer is the number one cause of death in Australia with colorectal cancer being the second most common cancer type. The translation of cancer research into clinical practice is hindered...
17.
Kuroiwa-Trzmielina J, Wang F, Rapkins R, Ward R, Buchanan D, Win A, et al.
Clin Cancer Res
. 2016 Jun;
22(24):6266-6277.
PMID: 27267851
Purpose: Methylation of the MGMT promoter is the major cause of O-methylguanine methyltransferase deficiency in cancer and has been associated with the T variant of the promoter enhancer SNP rs16906252C>T....
18.
Suraweera N, Mouradov D, Li S, Jorissen R, Hampson D, Ghosh A, et al.
Oncotarget
. 2016 May;
7(24):36474-36488.
PMID: 27167335
Telomeric dysfunction is linked to colorectal cancer (CRC) initiation. However, the relationship of normal tissue and tumor telomere lengths with CRC progression, molecular features and prognosis is unclear. Here, we...
19.
He E, Hawkins N, Mak G, Roncolato F, Goldstein D, Liauw W, et al.
Oncologist
. 2016 Mar;
21(5):618-25.
PMID: 27009937
Background: Testing for mismatch repair (MMR) status in colorectal cancer (CRC) may provide useful prognostic and predictive information. We evaluated the impact of such testing on real-world practice regarding adjuvant...
20.
Jorissen R, Christie M, Mouradov D, Sakthianandeswaren A, Li S, Love C, et al.
Br J Cancer
. 2015 Aug;
113(6):979-88.
PMID: 26305864
Background: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. Methods: APC prognostic value was evaluated in 746 stage I-IV CRC patients,...