Nicholas J Brandon
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Explore the profile of Nicholas J Brandon including associated specialties, affiliations and a list of published articles.
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113
Citations
4310
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Recent Articles
1.
Aikio M, Odeh H, Wobst H, Lee B, Chan U, Mauna J, et al.
Cell Rep
. 2025 Feb;
44(3):115386.
PMID: 39977265
No abstract available.
2.
Aikio M, Odeh H, Wobst H, Lee B, Chan U, Mauna J, et al.
Cell Rep
. 2025 Jan;
44(1):115205.
PMID: 39817908
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder typically characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood. Persistent activation of p38...
3.
Kim S, Seo S, Stein-OBrien G, Jaishankar A, Ogawa K, Micali N, et al.
Stem Cell Reports
. 2024 Aug;
19(9):1336-1350.
PMID: 39151428
Variability between human pluripotent stem cell (hPSC) lines remains a challenge and opportunity in biomedicine. In this study, hPSC lines from multiple donors were differentiated toward neuroectoderm and mesendoderm lineages....
4.
Cho N, Kontou G, Smalley J, Bope C, Dengler J, Montrose K, et al.
iScience
. 2024 May;
27(4):109512.
PMID: 38715938
LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy,...
5.
Jarvis R, Ng S, Nathanson A, Cardarelli R, Abiraman K, Wade F, et al.
Cell Rep Med
. 2023 Mar;
4(3):100957.
PMID: 36889319
Hyperpolarizing GABAR currents, the unitary events that underlie synaptic inhibition, are dependent upon efficient Cl extrusion, a process that is facilitated by the neuronal specific K/Cl co-transporter KCC2. Its activity...
6.
Jaaro-Peled H, Kumar S, Hughes D, Sumitomo A, Kim S, Zoubovsky S, et al.
Mol Psychiatry
. 2022 Feb;
27(3):1805-1815.
PMID: 35165396
Sensorimotor information processing underlies normal cognitive and behavioral traits and has classically been evaluated through prepulse inhibition (PPI) of a startle reflex. PPI is a behavioral dimension deregulated in several...
7.
Lee K, Abiraman K, Lucaj C, Ollerhead T, Brandon N, Deeb T, et al.
Brain
. 2021 Sep;
145(3):950-963.
PMID: 34528073
First-in-line benzodiazepine treatment fails to terminate seizures in about 30% of epilepsy patients, highlighting a need for novel anti-seizure strategies. It is emerging that impaired K+/Cl- cotransporter 2 (KCC2) activity...
8.
Lopez-Domenech G, Howden J, Covill-Cooke C, Morfill C, Patel J, Burli R, et al.
EMBO J
. 2021 Jun;
40(14):e100715.
PMID: 34152608
Clearance of mitochondria following damage is critical for neuronal homeostasis. Here, we investigate the role of Miro proteins in mitochondrial turnover by the PINK1/Parkin mitochondrial quality control system in vitro...
9.
Walczyk-Mooradally A, Holborn J, Singh K, Tyler M, Patnaik D, Wesseling H, et al.
J Neurochem
. 2021 Jun;
158(5):1058-1073.
PMID: 34077555
Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene product that support neuroplastic changes important for cognitive function and memory formation. As a protein with homology to the retroviral Gag...
10.
Kontou G, Ng S, Cardarelli R, Howden J, Choi C, Ren Q, et al.
J Biol Chem
. 2021 Feb;
296:100364.
PMID: 33539918
The K/Cl cotransporter KCC2 (SLC12A5) allows mature neurons in the CNS to maintain low intracellular Cl levels that are critical in mediating fast hyperpolarizing synaptic inhibition via type A γ-aminobutyric...