Tarek Z Deeb
Overview
Explore the profile of Tarek Z Deeb including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
41
Citations
1460
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Cho N, Kontou G, Smalley J, Bope C, Dengler J, Montrose K, et al.
iScience
. 2024 May;
27(4):109512.
PMID: 38715938
LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy,...
2.
Jarvis R, Ng S, Nathanson A, Cardarelli R, Abiraman K, Wade F, et al.
Cell Rep Med
. 2023 Mar;
4(3):100957.
PMID: 36889319
Hyperpolarizing GABAR currents, the unitary events that underlie synaptic inhibition, are dependent upon efficient Cl extrusion, a process that is facilitated by the neuronal specific K/Cl co-transporter KCC2. Its activity...
3.
Lee K, Abiraman K, Lucaj C, Ollerhead T, Brandon N, Deeb T, et al.
Brain
. 2021 Sep;
145(3):950-963.
PMID: 34528073
First-in-line benzodiazepine treatment fails to terminate seizures in about 30% of epilepsy patients, highlighting a need for novel anti-seizure strategies. It is emerging that impaired K+/Cl- cotransporter 2 (KCC2) activity...
4.
Smalley J, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, et al.
Front Mol Neurosci
. 2020 Nov;
13:563091.
PMID: 33192291
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address...
5.
Tejeda G, Whiteley E, Deeb T, Burli R, Moss S, Sheridan E, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(1):677-688.
PMID: 31871190
A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in...
6.
Plumbly W, Brandon N, Deeb T, Hall J, Harwood A
Sci Rep
. 2019 Sep;
9(1):13810.
PMID: 31554851
The combination of in vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capability to study human neuronal networks from patient or engineered human cell lines....
7.
Moore Y, Conway L, Wobst H, Brandon N, Deeb T, Moss S
Front Mol Neurosci
. 2019 Aug;
12:173.
PMID: 31396048
GABA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the...
8.
Moore Y, Deeb T, Chadchankar H, Brandon N, Moss S
Proc Natl Acad Sci U S A
. 2018 Sep;
115(40):10166-10171.
PMID: 30224498
The type 2 K/Cl cotransporter (KCC2) allows neurons to maintain low intracellular levels of Cl, a prerequisite for efficient synaptic inhibition. Reductions in KCC2 activity are evident in epilepsy; however,...
9.
Kelley M, Cardarelli R, Smalley J, Ollerhead T, Andrew P, Brandon N, et al.
EBioMedicine
. 2018 Jun;
32:62-71.
PMID: 29884458
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K/Cl co-transporter 2 (KCC2) is a...
10.
Fan J, Zhao R, Parro C, Zhao W, Chou H, Robert J, et al.
J Lipid Res
. 2018 Mar;
59(5):830-842.
PMID: 29563219
apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are...