Nicholas J Brandon
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Explore the profile of Nicholas J Brandon including associated specialties, affiliations and a list of published articles.
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113
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Recent Articles
11.
Smalley J, Kontou G, Choi C, Ren Q, Albrecht D, Abiraman K, et al.
Front Mol Neurosci
. 2020 Nov;
13:563091.
PMID: 33192291
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address...
12.
Silva M, Nandi G, Tentarelli S, Gurrell I, Jamier T, Lucente D, et al.
Nat Commun
. 2020 Jun;
11(1):3258.
PMID: 32591533
Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant phenotypes ex vivo that can be pharmacologically targeted for...
13.
Micali N, Kim S, Diaz-Bustamante M, Stein-OBrien G, Seo S, Shin J, et al.
Cell Rep
. 2020 May;
31(5):107599.
PMID: 32375049
Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use...
14.
Zhao W, Fan J, Kulic I, Koh C, Clark A, Meuller J, et al.
Mol Brain
. 2020 May;
13(1):66.
PMID: 32366277
Alzheimer's disease (AD), the leading cause of dementia, is a chronic neurodegenerative disease. Apolipoprotein E (apoE), which carries lipids in the brain in the form of lipoproteins, plays an undisputed...
15.
Erli F, Palmos A, Raval P, Mukherjee J, Sellers K, Gatford N, et al.
Transl Psychiatry
. 2020 Feb;
10(1):16.
PMID: 32066698
Loss of glutamatergic synapses is thought to be a key cellular pathology associated with neuropsychiatric disorders including schizophrenia (SCZ) and major depressive disorder (MDD). Genetic and cellular studies of SCZ...
16.
Wobst H, Mack K, Brown D, Brandon N, Shorter J
Med Res Rev
. 2020 Feb;
40(4):1352-1384.
PMID: 32043626
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of muscle function. It is the most common adult-onset form of motor neuron disease, affecting about 16 ...
17.
Burke E, Chenoweth J, Shin J, Collado-Torres L, Kim S, Micali N, et al.
Nat Commun
. 2020 Jan;
11(1):462.
PMID: 31974374
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal...
18.
Tejeda G, Whiteley E, Deeb T, Burli R, Moss S, Sheridan E, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(1):677-688.
PMID: 31871190
A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in...
19.
Chadchankar J, Korboukh V, Conway L, Wobst H, Walker C, Doig P, et al.
PLoS One
. 2019 Nov;
14(11):e0225145.
PMID: 31703099
USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has been considered a therapeutic strategy for accelerating...
20.
Moore Y, Conway L, Wobst H, Brandon N, Deeb T, Moss S
Front Mol Neurosci
. 2019 Aug;
12:173.
PMID: 31396048
GABA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the...